• Papillary thyroid cancer (PTC) tends to have an indolent clinical course with low morbidity and mortality. Nevertheless, this entity has a broad range of biologic and clinical behavior that can result in disease recurrence and death, depending on patient and tumor characteristics and the initial management approach.
• PTC is the most common form of well-differentiated thyroid cancer (WDTC) and based on the most recent statistics, accounts for approximately 89.4% of all thyroid malignancies, and is the predominant histology observed in patients exposed to radiation.
• The average age of diagnosis of PTC is between 30 and 40 years, women are affected more frequently than men at a 2:1 ratio.
• PTC appears as an irregular solid or cystic nodule in a normal thyroid parenchyma.
• Notwithstanding its well-differentiated characteristics, PTC may be blatantly or minimally invasive. In fact, these tumors may spread easily to other organs.
• PTC has the propensity for lymphatic invasion but it is less likely to have hematogenous spread. 
• Roughly 11% of patients with PTC present with distant metastases outside the neck and mediastinum.
• In the past, regional lymph node metastases were thought to be aberrant (supernumerary) thyroids because they contained well-differentiated PTC, but occult regional lymph node metastases are now known to be a very common finding in patients with PTC.

#Arrangoiz #CancerSurgeon #ThyroidSurgeon #HeadandNeckSurgeon #SurgicalOncologist #ThyroidCancer #PapillaryThyroidCancer #PTC #CASO #CenterforAdvancedSurgicalOncology

👉If you have thyroid nodules, there are some things you need to know.

👉By the age of 60, more than half of women will have a thyroid nodule.

👉Recent studies show that most are benign (not cancerous), but 4.0% to 6.5% of end up being cancer.

👉Here is what you need to pay attention to:

1. If you find out you have a thyroid nodule, check your thyroid functions to see if your thyroid functions normally. It is important to have your thyroid functions regularly monitored.
2. Risk factors for developing a thyroid nodule: radiation, smoking, obesity, metabolic syndrome, alcohol consumption and uterine fibroids.
3. Biopsy (an examination of the tissue) is needed if thyroid nodules are larger than 1 cm. If your nodule is larger than 1 cm, you experience any thyroid pain or shortness of breath and you have difficulty swallowing, you should consult with your doctor immediately.
4. If your nodule is smaller than 1 cm, it is important to regularly consult with your doctor to discover any changes in the nodule in time.
5. Zamora EA, Khare S, Cassaro S. Thyroid Nodule. In: StatPearls Publishing. 2020 January.

#Arrangoiz #ThyroidSurgeon #ThyroidExpert #EndocrineSurgery #HeadandNeckSurgery #CancerSurgeon #CASO #CenterforAdvancedSurgicalOncology #PalmettoGeneralHospital

• Obesity has repeatedly been cited as a possible etiologic factor in the pathogenesis of thyroid cancer and has been postulated to be a possible origin of the increase incidence of this disease worldwide.
• Undeniably, being overweight and obesity have been associated with an increased risk of developing numerous malignancies, including thyroid, breast, colorectal, kidney, and endometrial cancers.
• In the United States from 1995 to 2015, one out of every six PTC and two thirds of PTC greater than 4 cm in size have been linked to being overweight or obesity, based on an analysis of data from three large national US databases.
• Kitahara et al projected that the total relative risk for PTC was 1.26 for persons who are overweight (body mass index [BMI] 25 to 29 kg/m2) and 1.30 for those who are obese (BMI ≥ 30  kg/m2), compared with persons with normal-weight BMI (18.5 to 24.9 kg/m2).
• The risk in PTCs greater than 4 cm in size was nearly 3-fold higher (hazard ratio [HR] = 2.93, 95% CI 1.25-6.87) with overweight individuals, and more than 5-fold higher (HR = 5.42, 95% CI 2.24-13.1) in obese individuals compared with normal-weight individuals.
• A study by Leitzmann et al, found that obese adults had a nearly 40% higher risk for developing thyroid cancer when compared with normal-weight individuals.
• More research is needed to define the exact role of obesity in the development of thyroid cancer, particularly as the incidence of obesity continues to climb throughout the world. 

• References:
  • Society, A.C., American Cancer Society: Cancer Facts and Figures 2018., A.C. Society, Editor. 2018: Atlanta, Ga.
  • Brindel, P., et al., Anthropometric factors in differentiated thyroid cancer in French Polynesia: a case-control study.Cancer Causes Control, 2009. 20(5): p. 581-90.
  • Dal Maso, L., et al., A pooled analysis of thyroid cancer studies. V. Anthropometric factors. Cancer Causes Control, 2000. 11(2): p. 137-44.
  • Kitahara CM, P.R., Sosa JA, Shiels MS, Impact of overweight and obesity on U.S. papillary thyroid cancer incidence trends (1995-2015). J Natl Cancer Inst, 2019.
  • Leitzmann, M.F., et al., Prospective study of body mass index, physical activity and thyroid cancer. Int J Cancer, 2010. 126(12): p. 2947-56.
  • Berghofer, A., et al., Obesity prevalence from a European perspective: a systematic review. BMC Public Health, 2008. 8: p. 200.
  • Wang, Y. and M.A. Beydoun, The obesity epidemic in the United States–gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev, 2007. 29: p. 6-28.

#Arrangoiz #CancerSurgeon #ThyroidSurgeon #EndocrineSurgery #HeadandNeckSurgeon #CASO #CenterforAdvancedSurgicalOncology

• The facial artery (external maxillary artery in some texts):
  • Is a branch of the external carotid artery that supplies structures of the superficial face
• The facial artery arises in the carotid triangle:
  • From the external carotid artery:
    • A little above the lingual artery:
      • Sheltered by the ramus of the mandible
    • It passes obliquely up beneath the digastric and stylohyoid muscles:
      • Over which it arches to enter a groove on the posterior surface of the submandibular gland
      • It then curves upward over the body of the mandible at the antero-inferior angle of the masseter:
        • Passes forward and upward across the cheek to the angle of the mouth, then ascends along the side of the nose, and ends at the medial commissure of the eye, under the name of the angular artery
• The facial artery is remarkably tortuous:
  • This is to accommodate itself to neck movements such as those of the pharynx in deglutition; and facial movements such as those of the mandible, lips, and cheeks
• In the neck, its origin is superficial, being covered by the integument, platysma, and fascia:
  • It then passes beneath the digastric and stylohyoid muscles and part of the submandibular gland, but superficial to the hypoglossal nerve

• It lies upon the middle pharyngeal constrictor and the superior pharyngeal constrictor, the latter of which separates it, at the summit of its arch, from the lower and back part of the tonsil
• On the face, where it passes over the body of the mandible, it is comparatively superficial, lying immediately beneath the dilators of the mouth
• In its course over the face, it is covered by the integument, the fat of the cheek, and, near the angle of the mouth, by the platysma, risorius, and zygomaticus major
• It rests on the buccinator and levator anguli oris, and passes either over or under the infraorbital head of the levator labii superioris
• The anterior facial vein lies lateral / posterior to the artery, and takes a more direct course across the face, where it is separated from the artery by a considerable interval. In the neck it lies superficial to the artery
• The branches of the facial nerve cross the artery from behind forward
• The facial artery anastomoses with (among others) the dorsal nasal artery of the internal carotid artery
• The branches of the facial artery are:
  • Cervical:
    • Ascending palatine artery
    • Tonsillar branch
    • Submental artery
    • Glandular branches
  • Facial:
    • Inferior labial artery
    • Superior labial artery
    • Lateral nasal branch to nasalis muscle
    • Angular artery – the terminal branch
• Muscles supplied by the facial artery include:
  • Buccinator
  • Levator anguli oris
  • Levator labii superioris
  • Levator labii superioris alaeque nasi
  • Levator veli palatini
  • Masseter
  • Mentalis
  • Mylohyoid
  • Nasalis
  • Palatoglossus
  • Palatopharyngeus
  • Platysma
  • Procerus
  • Risorius
  • Styloglossus
  • Transverse portion of the nasalis

#Arrangoiz #HeadandNeckSurgeon #CancerSurgeon #Teacher #CASO #CenterforAdvancedSurgicalOncolgoy

• The larynx is an inferior continuation of the oropharynx:It extends from the epiglottis (namely the glossoepiglottic and pharyngoepiglottic folds) to the inferior aspect / border of the cricoid cartilage. Inferiorly:It continues as the cervical trachea. 
• Gross anatomy:The larynx consists of a cartilage “skeleton”, as well as internal structures that are divided into three subsites, mainly for the purposes of laryngeal cancer staging:Supraglottis: Which extends from the tip of the epiglottis to the laryngeal ventricle
  • • • Subsites:Epiglottis:Divided into suprahyoid and infrahyoid portionsPre-epiglottic spaceArytenoid cartilagesAryepiglottic foldsVentriclesFalse vocal cords
        • Paraepiglottic space
    • GlottisTrue vocal cordsAnterior commissurePosterior commissure
    • Subglottis: Extends from the inferior surface of the true vocal cords / 5mm below the free margin of the true vocal cord to the inferior aspect / lower border of the cricoid cartilage
• Relations:Anterior: Strap muscles
  • • Anterior jugular vein
  • Posterior: EsophagusLaryngopharynx
  • Superior: Hyoid boneLaryngopharynx
  • inferior: Trachea
• Arterial supply:Above the vocal cords: Superior laryngeal artery:Branch of the superior thyroid arteryBelow the vocal cords:Inferior laryngeal artery:
  • • • Branch of the inferior thyroid artery
• Venous drainageAbove the vocal cords: Superior laryngeal vein accompanies its artery and drains into the superior thyroid vein:A tributary to the internal jugular veinBelow the vocal cords: Inferior laryngeal vein accompanies its artery and drains into the inferior thyroid vein:A direct tributary to the brachiocephalic vein
• Lymphatic drainage:Supraglottic: The supraglottic lymphatic network follows the superior laryngeal artery:Piercing the thyrohyoid membrane and then draining into the superior deep cervical nodes and the pre-epiglottic nodes. Subglottic: The infraglotttic lymphatic network drains to the inferior deep cervical nodes, following the inferior laryngeal artery, and/or the prelaryngeal (Delphian) nodes via the conus elasticus (aka the lateral cricothyroid ligaments). Both the superior and inferior deep cervical nodes then drain into the right and left jugular trunks:Which subsequently empty into the right lymphatic duct and the thoracic duct on the left. 
• Innervation:Motor: The recurrent laryngeal nerve supplies all the intrinsic muscles of the larynx apart from the cricothyroid muscle:Which is supplied by the external branch of the superior laryngeal nerve.Sensory: Above the vocal cords (supraglottic): Internal branch of the  superior laryngeal nerveBelow the vocal cords (infraglottic): Recurrent laryngeal nerve
• Development:The larynx is formed from the laryngotracheal groove:Which is related to the caudal aspect of the floor of the primordial pharynxThe cartilages of the larynx develop from:The 4^th and 6^th pharyngeal arches

Staging of Laryngeal Cancer

• Rodrigo Arrangoiz MS, MD, FACS es especialista en Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina y Cirugía Oncológica compleja:
• Fue egresado como Médico General de la Universidad Anahuac:

• Graduado Suma Cum Laude. Es miembro de Center for Advanced Surgical Oncology
• El Doctor Arrangoiz es experto en el manejo del: Cáncer de Tiroides:Cáncer papilar de tiroides

• • • • Cáncer folicular de tiroides
      • Cáncer medular de tiroides
      • Cáncer anaplásico de tiroides
    • Patología Quirúrgica de Tiroides:Bocio multi nodular no toxico sintomático  Bocio multi nodular toxicoHipertiroidismo
    • Hiperparatiroidismo:Hiperparatiroidismo primarioHiperparatiroidismo secundarioHiperparatiroidismo terciario
    • Tumores de Cabeza y Cuello:Cancer de la cavidad oral
      • Cáncer de faringe:
        • Nasofaringe
        • Orofaringe
        • Hipofaringe
      • Cáncer Laringeo:
        • Cáncer supraglótico
        • Cáncer glótico
        • Cancer subglótico
      • Cáncer de glándulas salivales:
        • Glándula Parótida
        • Glándula submandibular
        • Glándula sublingual
        • Glándulas salivales menores
      • Cáncer de piel de la cabeza y cuello:
        • Melanoma
        • Carcinoma basocelular
        • Carcinoma epidermoide
        • Carcinoma de Merkel
        • Dermatofibrosacroma Protuberans
      • Cáncer de Mama. 
      • Cáncer de piel:
        • Melanoma
        • Carcinoma basocelular
        • Carcinoma epidermoide
        • Carcinoma de Merkel
        • Dermatofibrosacroma Protuberans
  • Fue entrenado en las mejores instituciones académicas de los Estados Unidos.
  • Mantiene certificaciones por los Consejos de Cirugía General y Cirugía Oncológica en México y en los Estados Unidos de América. 
     
• Su entrenamiento incluyó:Cirugía General y Gastrointestinal:Michigan State University (2004 – 2010)

• Cirugía Oncológica / Tumores de Cabeza y Cuello / Cirugía Endocrina:Fox Chase Cancer Center en Filadelfia (2010 al 2012)

• Maestría en Ciencias (Clinical Research for Health Professionals):Drexel University (Filadelfia) (2010 – 2012)

• Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina (2014 al 2016):IFHNOS / Memorial Sloan Kettering Cancer Center

• Ha participado en múltiples cursos y congresos como Conferencista y Profesor Invitado, así mismo ha realizado diversas publicaciones y artículos sobre temas relacionados con su especialidad.
• Fue pionero en México de la:
  • Cirugía minimamente invasive radioguida de paratiroides.
• Se encuentra certificado por el Consejo Mexicano de Cirugía General y el Consejo Mexicano de Oncología así como es de los pocos mexicanos certificado por, el AMERICAN BOARD OF SURGERY,  el cuál le faculta como cirujano con licencia en los EU.
• Es miembro de diversas asociaciones médicas como el:American College of Surgeons, American Thyroid Association, American Society of Endocrine Surgeons, American Medical Association, American Society of Clinical Oncology, Association of Academic Surgeons, Society of Surgical Oncology,  The Society of Surgery of the Alimentary Tract, Society of American Gastrointestinal Endoscopic Surgeons, y la American Society of Breast Surgeons, entre otras.
• Gracias a esto el Dr. Rodrigo Arrangoiz es reconocido como uno de los mejores especialistas en Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina y Cirugía Oncológica en México, además de ser galardonado como uno de los 50 mejores médicos de México en los Top Doctors Awards 2018.

#Arrangoiz

#Teacher

#Surgeon

#Cirujano

#ThyroidExpert

#ThyroidSurgeon

#CirujanodeTiroides

#ExpertoenTiroides

#ExpertoenParatiroides

#Paratiroides

#Hiperparatiroidismo

#CancerdeTiroides

#ThyroidCancer

#PapillaryThyroidCancer

#SurgicalOncologist

#CirujanoOncologo

#CancerSurgeon

#CirujanodeCancer

#HeadandNeckSurgeon

#CirugiaEndocrina

#CirujanodeTumoresdeCabezayCuello

#OralCavityCancer

#Melanoma

• The scalp refers to the layers of skin and subcutaneous tissue that cover the bones of cranial vault
• Layers of the Scalp:
  • The scalp consists of five layers
  • The first three layers are tightly bound together:
    • Move as a collective structure
  • The mnemonic ‘SCALP’ can be a useful way to remember the layers of the scalp:
    • Skin
    • Dense Connective Tissue
    • Epicranial Aponeurosis (Galea Aponeurotica)
    • Loose Areolar Connective Tissue
    • Periosteum
  • Skin:
    • Contains numerous hair follicles and sebaceous glands:
      • Thus a common site for sebaceous cysts
  • Dense Connective tissue:
    • Connects the skin to the epicranial aponeurosis
    • It is richly vascularized and innervated
    • The blood vessels within the layer are highly adherent to the connective tissue:
      • This renders them unable to constrict fully if lacerated:
        • And so the scalp can be a site of profuse bleeding
  • Epicranial Aponeurosis:
    • A thin, tendon-like structure that:
      • Connects the occipitalis and frontalis muscles
  • Loose Areolar Connective Tissue:
    • A thin connective tissue layer that:
      • Separates the periosteum of the skull from the epicranial aponeurosis
    • It contains numerous blood vessels, including emissary veins:
      • Which connect the veins of the scalp to the diploic veins and intracranial venous sinuses
  • Periosteum:
    • The outer layer of the skull bones
    • It becomes continuous with the endosteum at the suture lines

• Arterial Supply:
  • The scalp receives a rich arterial supply via the:
    • External carotid artery
    • The ophthalmic artery:
      • A branch of the internal carotid
  • There are three branches of the external carotid artery involved:
    • Superficial temporal artery:
      • Supplies the frontal and temporal regions
    • Posterior auricular artery :
      • Supplies the area superiorly and posteriorly to the auricle
    • Occipital artery:
      • Supplies the back of the scalp
  • Anteriorly and superiorly, the scalp receives additional supply from two branches of the ophthalmic artery:
    • The supraorbital and supratrochlear arteries:
      • These vessels accompany the supraorbital and supratrochlear nerves respectively

• Venous drainage:
  • The venous drainage of the scalp can be divided into:
    • Superficial and deep components
  • The superficial drainage follows the arterial supply:
    • Superficial temporal, occipital, posterior auricular, supraorbital and supratrochlear veins
  • The deep (temporal) region of the skull is drained by:
    • The pterygoid venous plexus:
      • This is a large plexus of veins situated between the temporalis and lateral pterygoid muscles:
        • Drains into the maxillary vein
  • Importantly, the veins of the scalp connect to the diploic veins of the skull:
    • Via valveless emissary veins:
      • This establishes a connection between the scalp and the dural venous sinuses

• Innervation:
  • The scalp receives cutaneous innervation from branches of the:
    • Trigeminal nerve or the cervical nerve roots
  • Trigeminal Nerve:
    • Supratrochlear nerve:
      • Branch of the ophthalmic nerve:
        • Which supplies the anteromedial forehead
    • Supraorbital nerve:
      • Branch of the ophthalmic nerve:
        • Which supplies a large portion of the scalp between the anterolateral forehead and the vertex
    • Zygomaticotemporal nerve:
      • Branch of the maxillary nerve:
        • This supplies the temple
    • Auriculotemporal nerve:
      • Branch of the mandibular nerve:
        • Which supplies skin anterosuperior to the auricle
  • Cervical Nerves:
    • Lesser occipital nerve:
      • Derived from the anterior ramus (division) of C2 and supplies the skin posterior to the ear
    • Greater occipital nerve:
      • Derived from the posterior ramus (division) of C2 and supplies the skin of the occipital region
    • Great auricular nerve:
      • Derived from the anterior rami of C2 and C3 and supplies the skin posterior to the ear and over the angle of the mandible.
    • Third occipital nerve:
      • Derived from the posterior ramus of C3 and supplies the skin of the inferior occipital region

#Arrangoiz #HeadandNeckSurgeon #CancerSurgeon #SCALP #ScalpAnatomy #SkinCancer #CASO #CenterforAdvancedSurgicalOncology

👉Even if you are sure to identify #parathyroid glands, why do you still have postoperative #hypocalcemia?

👉Thinking that the parathyroid glands may have been localized is nice, but being sure is better.

👉In order to localize the parathyroid glands, even before your expert eyes, use #autofluorescence #imaging in early stages during #thyroidectomy.

👉Early localization of parathyroid glands helps to improve the early postoperative hypocalcemia rate significantly and increase parathyroid preservation after total thyroidectomy.

👉Nice article about this topic:

https://pubmed.ncbi.nlm.nih.gov/31693081/

#Arrangoiz #ThyroidSurgeon #ThyroidExpert #Hypocalcemia #PostOperativeHypocalcemia #Hypoparathyroidism #AutoFluorescence #CASO #CenterforAdvancedSurgicalOncology

Most patients with cancer in the oral cavity are men, although the incidence of tongue cancer in women in the United States has progressively increased from 15% in the years 1927 – 1934 to 47% in the years 1988 – 1997.

Excerpt From: Jatin P. Shah, Snehal G. Patel & Bhuvanesh Singh. “Jatin Shah’s Head and Neck Surgery and Oncology.” iBooks. https://itunes.apple.com/us/book/jatin-shahs-head-and-neck-surgery-and-oncology/id535088692?mt=11

In the Western world, the tongue and floor of the mouth are the most common sites of origin for primary squamous cell carcinomas in the oral cavity.

• However, the retromolar trigone and buccal mucosa are the most frequently encountered primary sites in areas of the world where the chewing of tobacco and/or betel nuts is common.

👉The parathyroid glands arise from the 3rd (inferior) and 4th (superior) pharyngeal pouches and follow distinct paths as they descend into their normal locations. A thorough knowledge of the anatomy and embryology of the parathyroid glands is crucial to the parathyroid surgeon and will guide the search for ectopic glands when aberrant anatomy is encountered.

👉For example, when a missing inferior gland is noted, the thymus is a common ectopic location that should be investigated, as this structure also arises from the 3rd pouch. In addition to the thymus, ectopic parathyroids may be found high in the neck (undescended), in the chest, embedded in the thyroid gland or in the sheath surrounding the carotid artery and jugular vein.

#Arrangoiz #ParathyroidSurgeon #ThyroidSurgeon #HeadandNeckSurgeon #CancerSurgeon #CASO #CenterforAdvancedSurgicalOncology #EndocrineSurgery

Breast Cancer During Pregnancy

• Diagnosis of a breast cancer during pregnancy requires:
  • A complex treatment plan with multiple multidisciplinary providers:
    • From both oncology and obstetrics:
      • Coordinating the timing of cancer treatment and the delivery of a high-risk pregnancy
• Gestational or pregnancy-associated breast cancer:
  • Refers to any breast cancer diagnosed:
    • During pregnancy or within the first year after childbirth
  • This is a rare diagnosis:
    • Yet remains the most common cancer in pregnant women:
      • Affecting approximately 15 to 35 women per 100,000 deliveries:
        • Approximately 0.05%
  • The majority of pregnancy-associated breast cancers are:
    • Ductal in origin
    • More likely to be poorly-differentiated
    • ER negative or PR negative and HER2-positive compared to non-pregnant women
    • Present at advanced stages
  • Evaluation of a dominant breast mass should include:
    • Ultrasound and mammogram with fetal shielding, and core biopsy:
      • Interpretation of mammography can be difficult:
        • In the highly dense tissue of pregnant women
      • Use of MRI during pregnancy is both contraindicated and unhelpful:
        • Gadolinium contrast may cause fetal harm during the first trimester and is typically avoided
    • Although the majority (approximately 80%) of breast biopsies in pregnant women will be benign:
      • It is critical that malignancy be ruled out
    • Fine needle aspiration during pregnancy is associated with a higher rate of false positive and false negative results:
      • Without receipt of tumor markers:
        • Therefore core biopsy is recommended
    • Staging should be performed in women with advanced disease, and in those with symptoms concerning for metastases:
      • This should include:
        • Chest radiograph with fetal shielding, liver ultrasound or MRI without contrast, and “low-dose” radionuclide bone scans
  • When possible, treatment of pregnancy-associated breast cancers:
    • Should follow similar guidelines to non-pregnant patients, and if at all possible, the pregnancy should be carried to term
  • Systemic treatment of breast cancer during pregnancy involves special consideration of both the mother and baby
    • Surgery is safe at all stages
  • Chemotherapy can be delivered from:
    • 14 weeks of gestation following completion of organogenesis through 35 weeks, when it should be stopped to avoid leukopenia in preparation for delivery
  • Data from a single-institution prospective study indicates that:
    • FAC chemotherapy (5-FU, doxorubicin, and cyclophosphamide) is safe during the second and third trimesters:
      • With fetal malformations approximating 1%
  • Experience with taxanes remained limited:
    • But the National Comprehensive Cancer Network (NCCN) guidelines recommend weekly paclitaxel if warranted
  • Methotrexates are contraindicated due to teratogenic side effects
  • Although, 20% of pregnancy-associated breast cancers are HER2-positive:
    • Anti-HER2 therapy including trastuzumab has not been proven safe during pregnancy and is best delivered in the adjuvant setting
    • MotHER, a prospective U.S. registry:
      • Is evaluating women exposed to trastuzumab +/- pertuzumab during pregnancy or within 6 months of conception and following pregnancy outcomes and infants for the first month of life
    • Current recommendations suggest that targeted anti-HER2 therapy be delayed until after delivery
  • Breast conservation is not recommended if radiation would be timed during pregnancy because this is contraindicated:
    • However, it can be performed if radiation falls after delivery
  • Axillary lymph node dissection was previously recommended:
    • But sentinel lymph node biopsy is feasible and should be offered
  • Hormone therapy should be postponed until after childbirth
  • Chemotherapy during pregnancy can cause concerns for the fetus which depend on the timing of drug administration:
    • Congenital malformations can occur in the first trimester
    • In the second and third trimesters:
      • Prematurity, low birth weight and myelosuppression are the greatest concerns
    • Among approved chemotherapy agents, long-term outcomes of children with in-utero exposure demonstrate normal development, cognition, and school performance when prematurity is controlled for
• References
  • Macdonald HR Pregnancy associated breast cancer. Breast J. 2020 Jan 14. doi: 10.1111/tbj.13714. [Epub ahead of print]
  • Goidescu I, Nemeti G, Caracostea G, Eniu DT, Chiorean A, Pintican R, Cruciat G, Muresan D. The role of imaging techniques in the diagnosis, staging and choice of therapeutic conduct in pregnancy associated breast cancer. Med Ultrason. 2019 Aug 31;21(3):336-343. doi: 10.11152/mu-1958. Review.

#Arrangoiz #BreastSurgeon #BreastCancer #CancerSurgeon #SurgicalOncology #CASO #CenterforAdvancedSurgicalOncology