Multifocal Ductal Carcinoma In Situ (DCIS)

  • Multifocal DCIS is generally defined as:
    • DCIS present as two or more foci separated by at least 5 mm within the same breast quadrant
  • Most investigators believe that multifocal disease:
    • In fact represents intraductal spread from a single focus of DCIS
  • By careful serial subsectioning, Holland et al. (1990):
    • Demonstrated that multifocal lesions that appeared to be separate using traditional pathologic techniques:
      • Actually originated from the same focus in 81 of 82 mastectomy specimens

#Arrangoiz #CancerSurgeon #BreastSurgeon #SurgicalOncologist #BreastCancer #LCIS #DCIS #DuctalCarcinomaInsitu #LobularNeoplasia #LobularCarcinomaInsitu #Surgeon #Teacher #Miami #Mexico #MSMC #MountSinaiMedicalCenter

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