High-Risk Assessment of Early Breast Cancer II

  • Although women with at least one first-degree relative with a history of breast cancer have a two- to three fold excess risk of developing the disease, only 5% to 10% have an identifiable hereditary predisposition
  • On average, women with a germline BRCA1 mutation have a 72% risk of developing breast cancer by age 80 years
  • For those with a germline BRCA2 mutation, the risk is 69%
  • The highest rates of BRCA1 mutations occur among Ashkenazi Jewish women
  • Because of the high lifetime risk for breast cancer in germline BRCA mutation carriers, both American and European guidelines recommend considering prophylactic surgery, such as double mastectomy
  • Other women at high risk of developing breast cancer because of a hereditary predisposition may opt for frequent imaging
  • Breast cancers that develop in germline BRCA1 mutation carriers are more likely to be high-grade, as well as triple-negative or basal-like subtype, whereas those with BRCA2 mutations are more likely to develop a high-grade, hormone receptor–positive/HER2-negative tumor
#Arrangoiz #BreastSurgeon #CancerSurgeon #SurgicalOncologist #MountSinaiMedicalCenter #MSMC #Miami #Mexico #BreastCancer

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