Epidemiology of Primary Hyperparathyroidism

  • Primary hyperparathyroidism (PHPT):
    • There are approximately 100,000 new cases per year reported in the United States
    • Since the advent of routine laboratory testing:
      • The prevalence of the disease has increased from:
        • 0.1% to 0.4%:
          • One to seven cases per 1000 adults
    • In a study by Yeh et al:
      • The incidence of PHPT fluctuated between:
        • 36.3 and 120.2 cases per 100,000 women-years
        • 13.4 and 35.6 cases per 100,000 men-years
    • PHPT may present at any age:
      • With the vast majority of cases occur in patients:
        • Older than 45 years of age
      • The mean age at diagnosis has remained between:
        • 52 and 56 years
    • Women have consistently made up the preponderance of cases:
      • With a female-to-male ratio of:
        • 3:1 to 4:1
      • Based on a population based study from Rochester Minnesota:
        • The higher incidence of this could be secondary (hypothetically) to:
          • Estrogen deficiency after menopause:
            • That reveals underlying HPT

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