Metaplastic Carcinoma of the Breast

  • Metaplastic carcinoma of the breast:
    • Tends to present in patients age 60 years and older
      • Is rare in young or premenopausal women
    • Compared to IDC:
      • It has been shown to present in a higher proportion of African Americans and Hispanics
  • Metaplastic breast cancer (MBC):
    • Is more likely to be high grade but axillary node negative at presentation
    • The mean tumor size:
      •  Is about 4 cm
    • Patients with this diagnosis are also more likely to receive chemotherapy and undergo mastectomy
    • Recurrence tends to be locoregional or pulmonary:
      • And is associated with a high mortality rate
  • Future directions may include immunotherapies:
    • As MBC has a unique histology, demonstrating increased PDL-1:
      • Which may make it a good candidate for targeted therapy:
        • More research is needed on this unique tumor phenotype
  • References
  • Pezzi CM, Patel-Parekh L, Cole K, Frank J, Klimberg VS, Bland K. Characteristics and treatment of metaplastic breast cancer: analysis of 892 cases from the National Cancer Data Base. Ann Surg Oncol. 2006;14(1):166-173.
  • Schwartz T, Mogal H, Papageorgiou C, Veerapong J, Hsueh EC. Metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies. Exp Hematol Oncol. 2013;(1)2:31.
  • Haque W, Teh BS. Current practice and future directions for metaplastic breast cancer. Ann Surg Oncol. 2018;25(Suppl 3):630-631.

#Arrangoiz #BreastSurgeon #BreastCancer #MetaplasticBreastCancer #SurgicalOncology #CancerSurgeon #Miami #CASO #CenterforAdvancedSurgicalOncology

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