👉Parathyroid hormone (PTH) and PTH-related peptide (PTHrP) both bind and activate one receptor, the G protein-coupled PTH/PTHrP receptor, yet they fulfill very different biological functions – Dr. Rodrigo Arrangoiz
👉PTH is primarily produced in the parathyroid chief cells and is the major regulator of serum calcium.
👉When the level of blood calcium falls, PTH is released from the parathyroid glands and then functions to increase the level of blood calcium.
👉When the level of blood calcium rises, PTH secretion is suppressed.
👉This classic endocrine feedback loop stabilizes the level of blood calcium within a narrow range.
👉PTHrP, by contrast, is expressed in most tissues of the human body and acts locally as a paracrine/autocrine factor.
👉During fetal development and during lactation, PTHrP also acts as a hormone regulating calcium homeostasis.
👉Para más información: http://www.hiperparatiroidismo.info
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