NSABP B-23

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  • NSABP B-23:
    • Was developed in an attempt to determine whether:
      • Tamoxifen was effective:
        • In patients with ER-negative tumors:
          • By randomizing them to:
            • Four cycles of adjuvant doxorubicin and cyclophosphamide (AC) or
            • Six cycles of adjuvant cyclophosphamide, methotrexate, and fluorouracil (CMF):
              • With or without tamoxifen
    • The results of B-23 demonstrated:
      • No significant improvement in:
        • Disease-free survival (DFS) or OS:
          • With tamoxifen added to chemotherapy in patients with ER-negative tumors:
            • DFS:
              • CMF – 83%
              • CMF plus tamoxifen – 83%
              • AC – 83%
              • AC plus tamoxifen – 82%
            • OS:
              • CMF – 89%
              • CMF plus tamoxifen – 89%
              • AC – 90%
              • AC plus tamoxifen – 91%
    • Additionally:
      • NSABP B-23 confirmed the results of NSABP B-15:
        • That four cycles of AC are equivalent to 6 cycles of CMF:
          • In terms of DFS and OS

#Arrangoiz #BreastSurgeon #CancerSurgeon #SurgicalOncologist #Teacher

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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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