Nasopharyngeal Papillary Adenocarcinoma

  • Nasopharyngeal Papillary Adenocarcinoma (NPAC):
    • Epidemiology:
      • Patients ranged in age from 11 to 64 years:
        • Median = 37 years
      • The ratio of male to female patients:
        • Is 5:4
    • They most frequently present with:
      • Airway obstruction
    • Primary NPACs can be classified into two main categories with different morphological features and clinical behavior:
      • The conventional or mucosal surface origin type
      • The salivary gland type:
        • Two main pathological subtypes:
          • Adenoid cystic carcinoma and
          • Mucoepidermoid carcinoma
    • Histomorphologic evaluation show:
      • An invasive carcinoma:
        • With papillary and glandular features:
          • The tumor display transition from normal surface epithelium to neoplasm
      • Cytologically this tumors are:
        • Composed of moderately pleomorphic, columnar, and pseudostratified cells with eosinophilic cytoplasm:
          • The nuclei are round to oval
          • They have vesicular or optically clear chromatin
        • Histochemical analysis confirms:
          • The production of epithelial mucin
        • Immunohistochemical study demonstrated:
          • Diffuse keratin and epithelial membrane antigen reactivity
          • Focal carcinoembryonic antigen reactivity
        • No immunoreactivity was seen with:
          • S-100 protein
          • Glial fibrillary acidic protein, or
          • Thyroglobulin:
            • Taken together:
              • These findings indicate an origen:
                • From the nasopharyngeal surface epithelium
              • Help to differentiate these tumors from:
                • Seromucous gland lesions and
                • Metastatic papillary thyroid carcinoma
      • The biologic potential:
        • Is that of a low-grade malignant tumor
      • Simple and complete surgical excision:
        • Is the treatment of choice

#Arrangoiz #HeadandNeckSurgeon #CancerSurgeon #NasopharyngealCancer #Surgeon #Teacher

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