- Nasopharyngeal Papillary Adenocarcinoma (NPAC):
- Epidemiology:
- Patients ranged in age from 11 to 64 years:
- Median = 37 years
- The ratio of male to female patients:
- Is 5:4
- Patients ranged in age from 11 to 64 years:
- They most frequently present with:
- Airway obstruction
- Primary NPACs can be classified into two main categories with different morphological features and clinical behavior:
- The conventional or mucosal surface origin type
- The salivary gland type:
- Two main pathological subtypes:
- Adenoid cystic carcinoma and
- Mucoepidermoid carcinoma
- Two main pathological subtypes:
- Histomorphologic evaluation show:
- An invasive carcinoma:
- With papillary and glandular features:
- The tumor display transition from normal surface epithelium to neoplasm
- With papillary and glandular features:
- Cytologically this tumors are:
- Composed of moderately pleomorphic, columnar, and pseudostratified cells with eosinophilic cytoplasm:
- The nuclei are round to oval
- They have vesicular or optically clear chromatin
- Histochemical analysis confirms:
- The production of epithelial mucin
- Immunohistochemical study demonstrated:
- Diffuse keratin and epithelial membrane antigen reactivity
- Focal carcinoembryonic antigen reactivity
- No immunoreactivity was seen with:
- S-100 protein
- Glial fibrillary acidic protein, or
- Thyroglobulin:
- Taken together:
- These findings indicate an origen:
- From the nasopharyngeal surface epithelium
- Help to differentiate these tumors from:
- Seromucous gland lesions and
- Metastatic papillary thyroid carcinoma
- These findings indicate an origen:
- Taken together:
- Composed of moderately pleomorphic, columnar, and pseudostratified cells with eosinophilic cytoplasm:
- The biologic potential:
- Is that of a low-grade malignant tumor
- Simple and complete surgical excision:
- Is the treatment of choice
- An invasive carcinoma:
- Epidemiology:
#Arrangoiz #HeadandNeckSurgeon #CancerSurgeon #NasopharyngealCancer #Surgeon #Teacher
Rodrigo Arrangoiz MS, MD, FACS, FSSO 