Paraneoplastic Syndromes Associated with Nasopharyngeal Carcinoma

👉Paraneoplastic syndromes (PNS) represent the clinical manifestation of the remote and indirect effects produced by tumor metabolites or other products.

👉Paraneoplastic effects are not directly mediated by tumor invasion of normal tissue, or by the disruption of normal function of the involved organ, or by distant metastases.

👉More than 260 cases of nasopharyngeal carcinoma (NPC) associated with PNS have been reported in the literature.

👉These syndromes can be divided into six main groups:

  • Cutaneous or dermatologic
  • Endocrine
  • Hematologic
  • Osteoarticular or rheumatologic
  • Neurologic
  • Ocular

👉The most common dermatologic / cutaneous manifestation is dermatomyositis.

👉The most common endocrinologic manifestation of PNS in NPC is syndrome of inappropriate secretion of antidiuretic hormone and occasionally Cushing’s syndrome due to ectopic ACTH production.

👉The most common hematologic manifestation of a PNS in NPC is tumor fever and leukemoid reaction.

👉The most common osteoarticular or rheumatic syndromes of PNS in NPC are clubbing of the fingers and toes.

👉The most common neurologic manifestation of PNS in NPC is sensory neuropathy and demyelinating motor polyneuropathy.

👉The most common ocular manifestation of PNS in NPC is optic neuritis.

👉PNS may occur before the NPC is manifest, or while it is in an occult stage, and thus the possibility of NPC should be considered in patients with these various disorders.

👉While some PNS will respond to direct treatment, most often the PNS subsides in parallel to response of the NPC, and thus may be useful for monitoring tumor response or recurrence.

#Arrangoiz #HeadandNeckSurgeon #CancerSurgeon #SurgicalOncologist #HeadandNeckTumors

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