Micro invasive Breast Cancer

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  • In 1982, Lagios et al. introduced the term “microinvasion” in breast pathology as synonymous with invasion less than 1 mm.
      • Microinvasive carcinoma is characterized by the extension of cancer cells beyond the in-situ component (ductal carcinoma in situ and lobular carcinoma in situ) into the adjacent breast tissue with no focus more than 0.1 cm in greatest dimension Figure.
      When there are multiple foci of microinvasion, only the size of the largest focus is used to classify the lesion, and the size of the individual foci should not be added together.
      Lesions that fulfill this definition are staged T1mic.
      The tumor focus/foci must invade into non-specialized interlobular or interductal stroma.
      The cells deemed to be invasive must be distributed in a non-organoid pattern that does not represent tangential sectioning of a duct or a lobular structure with in-situ carcinoma.
      Tangentially sectioned in-situ carcinoma foci that simulate microinvasion are distributed in the specialized intralobular and periductal stroma and usually occur as compact groups of tumor cells that have a smooth border surrounded by a circumferential layer of myoepithelial cells and stroma or a thickened basement membrane.
      At sites of microinvasion, tumor cells are distributed singly or as small groups that have irregular shapes reminiscent of conventional invasive carcinoma with no particular orientation.
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    Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

    My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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