BRCA 1 and BRCA 2 Hereditary Breast Cancer

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  • BRCA1 and BRCA2:
    • Are genes that produce tumor suppressor proteins:
      • Which help repair damaged DNA
    • They are the most common gene alterations seen in the hereditary breast cancer population
      • They are associated with an increased risk of breast cancer:
        • Estimated to be 55% to 70% for BRCA 1 carriers and 45% to 70% in BRCA2 carriers by age 70
    • While both BRCA1 and BRCA2 mutations are associated with an increased risk of breast cancer:
      • BRCA1 breast cancers more commonly occur in younger, premenopausal women and are more likely to be triple negative
    • BRCA1 is associated with a higher risk of ovarian cancer compared to BRCA2:
      • With a lifetime risk of 40% to 45% in BRCA1 carriers compared to 15% to 20% in BRCA2 carriers
    • BRCA2 breast cancers:
      • More closely resemble the sporadic breast cancer pattern, with a predominance of hormone receptor positive cancers in women greater than 50 years
  • CHEK2 and PALB2:
    • Are moderate penetrance genes that are less common than BRCA mutations
    • Similar to BRCA 2 deleterious mutations:
      • CHEK2 and PALB2 mutations are associated with hormone receptor positive postmenopausal breast cancer
  • References
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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

1 thought on “BRCA 1 and BRCA 2 Hereditary Breast Cancer”

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