Precancerous Oral Lesions

  • Diagnosis of precancerous lesions or early cancer can be difficult]
  • Leukoplakia and erythroplakia:
    • Are precancerous lesions that have a varying risk of progression to malignancy
    • Conversion from leukoplakia to carcinoma:
      • Is reported in up to 5% to 7% of patients observed over several years
    • Leukoplakia develops as a result of:
      • Chronic irritation of the mucous membranes by carcinogens:
        • This irritation stimulates proliferation of epithelial and connective tissue
      • Histopathologic examination reveals:
        • Underlying hyperkeratosis associated with epithelial hyperplasia
    • In the absence of underlying dysplasia:
      • Leukoplakia rarely (less than 5 % to 7%) is associated with progression to malignancy
    • Keratoses of a variety of degrees:
      • Manifest as leukoplakia
Leukoplakia (hyperkeratosis) of the oral tongue
Discoid leukoplakia with hyperkeratosis of the undersurface
of the tongue
  • Red spots, friable adjacent normal mucosa, characterize erythroplakia:
    • It is associated with underlying epithelial dysplasia:
      • Has a much greater potential for malignancy than leukoplakia:
        • Carcinoma is found in nearly 30% to 40 % of cases of erythroplakia
    • Erythroplakia usually manifests as a pinkish, velvety flat
Erythroplakia of the left floor of the mouth
  • Speckled leukoplakia:
    • Has a particularly high incidence of malignant transformation:
      • Similar to erythroplakia
Speckled leukoplakia of the oral tongue

#Arrangoiz #CancerSurgeon #HeadandNeckSurgeon #SurgicalOncologist #ThyroidSurgeon #ParathyroidSurgeon #MountSinaiMedicalCenter #MSMC #Miami #Mexico


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