Clinically Evident Nodal Metastatic Melanoma

  • The Multicenter Selective Lymphadenectomy Trial 2 (MSLT-2) was published in June 2017:
    • Which evaluated completion lymphadenectomy versus active surveillance (with dissection if disease were identified):
      • Following positive sentinel lymph node biopsies for metastatic melanoma
    • It is important to remember this was for clinically-occult nodal disease only
  • The standard of care for clinically-evident (palpable or radiographic) nodal metastatic melanoma is:
    • Lymphadenectomy
  • References:
    • van Akkooi CJA. Surgical and Anatomic Considerations of Malignancies Affecting the Groin: Consideration for Melanoma. In: Delman K, Master V, eds. Malignancies of the Groin. Cham, Switzerland: Springer, 2018:63-74.
    • Song Y, Karakousis GC. Melanoma of Unknown Primary. J Surg Oncol. 2019; 119 (2) 232-241.

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