CLEOPATRA Study in Metastatic HER2+ Breast Cancer

  • The CLEOPATRA study:
    • Showed that the combination of docetaxel, trastuzumab, and pertuzumab:
      • Led to improved progression free survival (PFS) compared to docetaxel, trastuzumab, and placebo:
        • 18.5 months vs. 12.4 months
  • Surgery for the primary site is not indicated for patients with distant metastatic disease in the absence of symptoms


1. Baselga J, Cortés J, Kim SB, Im SA, Hegg R, Im YH, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. New Engl J Med.2012;366(2):109-119.

2. Swain SM, Baselga J, Kim SB, Ro J, Semiglazov V, Campone M, et al. Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N Engl J Med. 2015;372(8):724-734.

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