Immunohistochemical Result of 2+ (Equivocal): What HER2 / CEP17 Ratio and Copy Number is Considered Positive?

  • Per American Society of Clinical Oncology / College of American Pathologists (ASCO/CAP) guidelines:
    • Tumors with an immunohistochemical result of 2+ (equivocal):
      • HER2 / CEP17 ratio of > 2.0 and copy number of > 4.0:
        • Are considered positive

References

1. Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS, et al. Human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline focused update. J Clin Oncol. 2018;142(11):1364-1382.

2. Lin L, Sirohi D, Coleman JF, Gulbahce HE. American Society of Clinical Oncology/College of American Pathologists 2018 focused update of breast cancer HER2 FISH testing guidelines. results from a National Reference Laboratory. Am J Clin Pathol. 2019;152(4):479-485

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s