Classic Papillary Thyroid Cancer (PTC)

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  • The diagnosis of classic PTC requires nuclear features including:
    • Intranuclear inclusions and nuclear grooves
    • The nuclei are larger than usual and often overlap:
      • Some may appear empty and are often called “Orphan Annie eyes“
  • The nuclear features of PTC distinguish it from other tumors:
    • Enabling it to be diagnosed on fine-needle aspiration
  • In addition, the tumor architecture is characterized by:
    • Branching papillae with a central fibrovascular stalk
  • Psammoma bodies, or “ghosts” of infarcted papillae:
    • Are virtually pathognomonic of PTC:
      • These concentric, lamellated, calcified spheres may be seen in approximately 50% of cases
  • Classical PTC is typically unencapsulated with invasive and ill-defined margins:
    • Nevertheless, this common histologic type is generally associated with an excellent prognosis
Surgical specimen showing the classic histologic appearance of papillary thyroid cancer with papillary structure (branching papillae) and no follicles or colloid. Follicular development can be seen in some of these carcinomas (follicular variant of papillary thyroid cancer); in them, the diagnosis is made from the cytologic features of the cells.
FNA of a thyroid nodule showing papillary thyroid cancer. The cells and nuclei are large, and their cytoplasm has a “ground glass” appearance. Nucleoli are prominent, and the nuclei have clefts, grooves, and “holes” due to intranuclear cytoplasmic inclusions (“Orphan Annie eyes”).

#Arrangoiz #ThyroidSurgeon #ThyroidExpert #HeadandNeckSurgeon #CancerSurgeon #SurgicalOncologist #EndocrineSurgery #PapillaryThyroidCancer #PTC #Miami #Mexico #MountSinaiMedical Center #OrphanAnnieEyes

Unknown's avatar

Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

Leave a comment