Chemotherapy for Breast Cancer

Taxanes bind free tubulin and stabilize microtubules.

This inhibits the spindle apparatus needed for mitosis.

Cyclophosphamide is an alkylating agent, which forms DNA cross-linkages

Doxorubicin interferes with topoisomerase II.

Fluorouracil acts as a nucleotide analog

Trastuzumab targets the epidermal growth factor receptor.

Abal M, Andreu JM, Barasoain I. Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action. Curr Cancer Drug Targets. 2003;3:193-203.

Priestman T. The theoretical basis of cancer chemotherapy. In Cancer Chemotherapy in Clinical Practice. 2nd ed. London, UK: Springer-Verlag London; 2012:1-43.

Cancer Surgeon
Surgical Excellence / Excelencia Quirúrgica

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s