Chemotherapy for Breast Cancer

Taxanes bind free tubulin and stabilize microtubules.

This inhibits the spindle apparatus needed for mitosis.

Cyclophosphamide is an alkylating agent, which forms DNA cross-linkages

Doxorubicin interferes with topoisomerase II.

Fluorouracil acts as a nucleotide analog

Trastuzumab targets the epidermal growth factor receptor.

References
Abal M, Andreu JM, Barasoain I. Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action. Curr Cancer Drug Targets. 2003;3:193-203.

Priestman T. The theoretical basis of cancer chemotherapy. In Cancer Chemotherapy in Clinical Practice. 2nd ed. London, UK: Springer-Verlag London; 2012:1-43.

Cancer Surgeon
Surgical Excellence / Excelencia Quirúrgica

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