Hyperparathyroidism during Pregnancy

  • Hyperparathyroidism during pregnancy:
    • Is often unrecognized:
      • Is associated with a 3.5-fold increase in miscarriage
  • Loss of the pregnancy:
    • Most often occurs during the late second trimester
  • The incidence of hyperparathyroidism in pregnancy is:
    • 0.7%
  • Maternal complications include:
    • Hyperemesis
    • Nephrolithiasis
    • Pancreatitis
  • Fetal complications include:
    • Spontaneous abortion
    • Growth retardation
  • In those who reach delivery, neonatal complications include:
    • Hypocalcemic crisis:
      • Within the first few days of life
  • Calcimimetic medications:
    • Have not been used in the setting of hyperparathyroidism in pregnancy
  • Calcitonin:
    • Has no role in the management of hyperparathyroidism

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