Familial Nonmedullary Thyroid Cancer

  • FNMTC is most accurately defined by the presence of three or more first-degree relativeswith well-differentiated thyroid cancer
  • In families with only two affected members:
    • 38% actually have FNMTC
  • In families with three or more affected persons in a family:
    • Translates into a 96% likelihood of having a hereditary form of thyroid cancer
  • The pattern of inheritance appears to be autosomal dominant with incomplete penetrance
  • Patients with FNMTC:
    • May have a more aggressive tumor than their sporadic counterparts, as they had a shorter disease-free survival in a recent multicenter retrospective study:
      • However, no studies have shown a difference in mortality from FNMTC cancer

#Arrangoiz #ThyroidCancer #ThyroidExpert #ThyroidSurgeon #HeadandNeckSurgeon #CancerSurgeon #SurgicalOncologist #FNMTC #FamilialNonmedullaryThyroidCancer #Miami #MountSinaiMedicalCenter

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