Familial Adenomatous Polyposis Syndrome (FAP) and Thyroid Cancer

  • FAP is an autosomal dominant disorder:
    • That results from a mutation in the APC tumor suppressor gene on chromosome 5q21
  • The syndrome is characterized by the development of:
    • Multiple adenomatous polyps with a high malignant potential throughout the gastrointestinal tract during early adulthood
    • PTC occurs in approximately 2% of patients with FAP:
      • Young women, however, are at highest risk of developing thyroid cancer:
        • Their chance of being affected is 160 times higher than it is for women without FAP
      • These tumors are frequently associated with a cribriform growth pattern on histologic examination

#Arrangoiz # ThyroidSurgeon #HeadandNeckSurgeon #ThyroidExpert #CancerSurgeon #SurgicalOncologist #FamilialAdenomaousPolyposis #FAP #Miami #MountSinaiMedicalCenter

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