- According to the World Health Organization definition:
- Complex fibroadenoma is a fibroadenoma containing:
- Cysts greater than 3 mm in size
- Sclerosing adenosis
- Epithelial calcifications
- Papillary apocrine hyperplasia
- Complex fibroadenoma is a fibroadenoma containing:
- While this is a benign diagnosis:
- Some authors have reported a slightly increased risk of subsequent breast cancer development:
- On par with other proliferative lesions of the breast:
- About 2 to 3-fold
- Thus, the terminology “complex fibroadenoma” is not always employed
- About 2 to 3-fold
- On par with other proliferative lesions of the breast:
- Some authors have reported a slightly increased risk of subsequent breast cancer development:
- The term “complex” does not imply any relation to radial scar or epithelial atypia in the setting of a fibroadenoma
- References
- Tan PH, Tse G, Lee A, et al. Fibroepithelial tumours. In: Lakhani SR, Ellis IO, Schnit SJ Tan PH, van de Vijver MJ. eds. WHO Classification of Tumours of the Breast. Lyon: IARC Press, 2012:142-143.
- Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer WD Jr, Rados MS, et al. Long-term risk of breast cancer in women with fibroadenoma. N Engl J Med. 1994;331(1):10-15.
- Nassar A, Visscher DW, Degnim AC, Frank RD, Vierkant RA, Frost M, et al. Complex fibroadenoma and breast cancer risk: a Mayo Clinic Benign Breast Disease Cohort Study. Breast Cancer Res Treat.2015;153(2):397-405.
- Krings G, Bean GR, Chen YY. Fibroepithelial lesions; The WHO spectrum. Semin Diagn Pathol. 2017;34(5):438-452.
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Rodrigo Arrangoiz MS, MD, FACS, FSSO 