Tubular Carcinoma of the Breast

  • Tubular carcinoma:
    • Is a distinct histopathologic subtype of breast cancer:
      • Representing 1% to 2% of breast cancers diagnosed
    • It is a distinct entity:
      • From low-grade ductal carcinoma
    • The literature continues to suggest that is has an excellent prognosis:
      • With a very low likelihood of distant metastasis and excellent disease-free survival.
    • In select patients:
      • Adjuvant therapies may be omitted:
        • However, there is a still a risk of axillary nodal metastasis:
          • Sentinel lymph node biopsy is still recommended due to a 10% to 20% risk of lymphatic spread
          • Despite this finding, there is likely to be only one node involved:
            • This histopathologic subtype still conveys an excellent prognosis
    • Tubular carcinoma is more likely to be identified on:
      • Screening mammography and is more common in Caucasians than blacks
    • Emerging data suggest that adjuvant systemic therapy can likely be safely omitted, although it should still be discussed with the multidisciplinary team
  • References
    • Rakha EA, Lee AH, Evans AJ, et al: Tubular carcinoma of the breast: further evidence to support its excellent prognosis. J Clin Oncol. 2010;28(1):99-104.
    • Fedko MG, Scow JS, Shah SS, et al. Pure tubular carcinoma and axillary nodal metastases. Ann Surg Oncol. 2010;17(Suppl 3):338-342.
    • Anderson WF, Chu KC, Chang S, Sherman ME. Comparison of age-specific incidence rate patterns for different histopathologic types of breast carcinoma. Cancer Epidemiol Biomarkers Prev. 2004;13(7): 1128-1135.

#Arrangoiz #CancerSurgeon #BreastSurgeon #SurgicalOncologist #BreastCancer #TubularBreastCancer #CASO #Miami #CenterforAdvancedSurgicalOncology

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