Risk Reducing Salpingo Oophorectomy (RRSO)

  • BRCA1 carriers are at increased risk of:
    • Breast cancer
    • Ovarian cancer
    • Prostate cancer
    • Pancreatic cancer
    • Melanoma
  • Typically, risk reducing salpingo oophorectomy (RRSO):
    • Is recommended between:
      • Ages 35 to 40 in BRCA1 carriers
      • Ages 40 to 45 in BRCA2 carriers, or
      • When done having children
  • RRSO has been shown to reduce the risk of breast cancer:
    • In premenopausal women by:
      • About 50%
  • RRSO has also been shown to reduce the risk of:
    • Ovarian cancer by:
      • 80%
  • In women who have not undergone RRSO:
    • Surveillance with CA 125 and pelvic ultrasound:
      • May be considered at the clinician’s discretion beginning ages 30 to 35
  • References:
    • Rebbeck TR, Kauff ND, Domchek SM. Meta-analysis of risk reduction estimates associated with risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers. J Natl Cancer Inst. 2009;101(2):80-87.

#Arrangoiz #BreastSurgeon #CancerSurgeon #SurgicalOncologist #BRCA #RRSO #CASO Miami #CenterforAdvancedSurgicalOncology

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