- BRCA1 carriers are at increased risk of:
- Breast cancer
- Ovarian cancer
- Prostate cancer
- Pancreatic cancer
- Melanoma
- Typically, risk reducing salpingo oophorectomy (RRSO):
- Is recommended between:
- Ages 35 to 40 in BRCA1 carriers
- Ages 40 to 45 in BRCA2 carriers, or
- When done having children
- Is recommended between:
- RRSO has been shown to reduce the risk of breast cancer:
- In premenopausal women by:
- About 50%
- In premenopausal women by:
- RRSO has also been shown to reduce the risk of:
- Ovarian cancer by:
- 80%
- Ovarian cancer by:
- In women who have not undergone RRSO:
- Surveillance with CA 125 and pelvic ultrasound:
- May be considered at the clinician’s discretion beginning ages 30 to 35
- Surveillance with CA 125 and pelvic ultrasound:
- References:
- NCCN Guideline with NCCN Evidence Blocks™ – Breast Cancer Version 3.2019. National Comprehensive Cancer Network website. https://www.nccn.org/professionals/physician_gls/recently_updated.aspx. Accessed September 21, 2019.
- Rebbeck TR, Kauff ND, Domchek SM. Meta-analysis of risk reduction estimates associated with risk-reducing salpingo-oophorectomy in BRCA1 or BRCA2 mutation carriers. J Natl Cancer Inst. 2009;101(2):80-87.

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