Risk Reducing Mastectomy (RRM)

  • According to National Comprehensive Cancer Network (NCCN) guidelines:
    • Risk reducing mastectomy (RRM):
      • Should be routinely discussed with all of the following:
        • BRCA 1
        • BRCA 2
        • Li-Fraumeni syndrome
        • PTEN
        • History of mantle radiation prior to age 30
      • CHEK2 mutations do not require a RRM:
        • There is insufficient evidence in CHEK2 mutations to routinely recommend RRM
  • Risk-reducing mastectomy:
    • Has been shown to decrease the incidence of breast cancer by 90% or more in several studies
  • References
    • Hartmann LC, Lindor NM. The role of risk-reducing surgery in hereditary breast and ovarian cancer. N Engl J Med. 2016;374(5):454-468.
    • Rebbeck TR, Friebel T, Lynch HT, et al. Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group. J Clin Oncol. 2004;22(6):1055-1062.
    • Domchek SM, Friebel TM, Singer CF, et al. Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. JAMA 2010;304(9):967-975.

#Arrangoiz #BreastSurgeon #CancerSurgeon #SurgicalOncologist #CASO #Miami #CenterforAdvancedSurgicalOncology #BRCA #RRM #RiskReducingMastectomy

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