• SCC is the second most common cutaneous carcinoma:
    • Accounts for roughly 20% of all non-melanoma skin cancers (NMSCs)
    • SCC is responsible for:
      • The majority of deaths from NMSC
  • SCC develops from keratinocytes of the epidermis and has many clinical variants
  • It can arise from precursor lesions such as:
    • Actinic keratosis (AK)
    • Can develop at the base of a cutaneous horn
  • Uncommonly:
    • SCC presents de novo as a single lesion on otherwise normal appearing skin
  • The most common lesion is found on sun-damaged skin:
    • Especially on the head, neck, or arms
    • The lesions are usually red, poorly defined plaques or nodules with an ulcerated friable surface
  • Bowen disease, or SCC in situ:
    • Is characterized by a rapidly growing, well-demarcated ulcerating tumor:
      • In a pre-existing scaly, erythematous plaque:
        • Up to 5% of Bowen disease may become invasive
  • SCC has a higher metastatic potential than BCC:
    • With an overall 5-year recurrence and metastatic risk of:
      • 8% and 5%, respectively:
        • However, many factors affect the metastatic potential of any given tumor, and there are subgroups with higher risk
    • Regional lymph nodes:
      • Are the most common metastatic site, with distant sites such as bone, brain, and lungs occasionally reported
    • For tumors of the head and neck:
      • The parotid gland is a common site for metastases
    • In general, features that indicate high risk for metastasis also predict risk for recurrence

#Arrangoiz #CancerSurgeon #SurigcalOncology #SurgicalOncology #SCC #CASO #CenterforAdvancedSurgicalOncology #SkinCancer

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