- SCC is the second most common cutaneous carcinoma:
- Accounts for roughly 20% of all non-melanoma skin cancers (NMSCs)
- SCC is responsible for:
- The majority of deaths from NMSC
- SCC develops from keratinocytes of the epidermis and has many clinical variants
- It can arise from precursor lesions such as:
- Actinic keratosis (AK)
- Can develop at the base of a cutaneous horn
- Uncommonly:
- SCC presents de novo as a single lesion on otherwise normal appearing skin
- The most common lesion is found on sun-damaged skin:
- Especially on the head, neck, or arms
- The lesions are usually red, poorly defined plaques or nodules with an ulcerated friable surface
- Bowen disease, or SCC in situ:
- Is characterized by a rapidly growing, well-demarcated ulcerating tumor:
- In a pre-existing scaly, erythematous plaque:
- Up to 5% of Bowen disease may become invasive
- In a pre-existing scaly, erythematous plaque:
- Is characterized by a rapidly growing, well-demarcated ulcerating tumor:
- SCC has a higher metastatic potential than BCC:
- With an overall 5-year recurrence and metastatic risk of:
- 8% and 5%, respectively:
- However, many factors affect the metastatic potential of any given tumor, and there are subgroups with higher risk
- 8% and 5%, respectively:
- Regional lymph nodes:
- Are the most common metastatic site, with distant sites such as bone, brain, and lungs occasionally reported
- For tumors of the head and neck:
- The parotid gland is a common site for metastases
- In general, features that indicate high risk for metastasis also predict risk for recurrence
- With an overall 5-year recurrence and metastatic risk of:
#Arrangoiz #CancerSurgeon #SurigcalOncology #SurgicalOncology #SCC #CASO #CenterforAdvancedSurgicalOncology #SkinCancer
Rodrigo Arrangoiz MS, MD, FACS, FSSO 