👉Dynamic risk stratification to determine need or benefit of RAI treatment for thyroid cancer patients
👉Abstract: The term thyroid neoplasm incorporates tumors that originate from follicular cells and those that arise from parafollicular cells (C cells). Differentiated thyroid cancer, which originates from follicular cells, includes papillary thy- roid carcinoma (PTC), follicular thyroid carcinoma (FTC), oncocytic cell car- cinoma (Hürthle), poorly differentiated carcinoma, and anaplastic thyroid carcinoma (ATC). PTC tends to have an indolent clinical course with low morbidity and mortality. However, this entity has a broad range of biological and clinical behavior that can result in disease recurrence and death, de- pending on patient and tumor characteristics and the initial treatment ap- proach. PTC is the most common form of well-differentiated thyroid cancer (WDTC) and based on the most recent statistics, accounts for approximately 89.4% of all thyroid malignancies. PTC appears as an irregular solid or cystic nodule in normal thyroid parenchyma. PTC has the propensity for lymphatic invasion, but it is less likely to have hematogenous spread. Around 11% of patients with PTC present with distant metastases outside the neck and me- diastinum. This manuscript with review the current understanding of the ep- idemiology, pathology, molecular characteristics, prognostic factors, and dy- namic risk stratification of PTC centered on an evidence-based and persona- lized approach.
Thyroid Cancer, Papillary Thyroid Cancer, Papillary Thyroid Microcarcinoma, Thyroid Nodule, Thyroid Cancer Treatment, Molecular
👉Arrangoiz, R., De Llano, J.G., Mijares, M.F., Fernandez-Chri- stlieb, G., Vasudevan, V., Sastry, A., Legas- pi, A., Fernandez, J., de la Cruz, F., Corde- ra, F. and Margain, D. (2021) Current Un- derstanding of Papillary Thyroid Carcino- ma. International Journal of Otolaryngolo- gy and Head & Neck Surgery, 10, 184-221. https://doi.org/10.4236/ijohns.2021.103019