CALGB 9343 Trial

  • The Cancer and Leukemia Group B (CALGB) 9343 trial:
    • Enrolled 647 patients:
      • From 1994 until 1999
    • Long-term follow-up data:
      • Were published in 2013:
        • With a median follow-up of:
          • 12.6 years
      • Women age 70 years or older:
        • With clinical stage I:
          • cT1, cN0, cM0
          • ER-positive breast cancer
          • Treated by lumpectomy
      • Were randomly assigned to receive:
        • Tamoxifen plus radiation therapy (TamRT) or Tamoxifen alone (Tam)
        • At 10 years:
          • 98% of women:
            • Receiving TamRT were free from local and regional recurrences
          • Compared to 91% of those receiving Tam
        • The 10-year estimates of overall survival (OS) were:
          • 67% (95% confidence interval [CI], 62–72%) in the TamRT group versus
          • 66% (95% CI, 61%–71%) in the Tam group:
            • But the difference was not statistically significant
      • In addition to concluding that:
        • While RT (in addition to Tam):
          • Reduces locoregional recurrence:
            • The authors noted that “the impact of breast cancer in this select group of older women is much smaller than that of comorbid conditions”:
              • Only 3% of women in study have died as a result of breast cancer whereas 49% have died as a result of other causes
  • References:
    • Hughes KS, Schnaper LA, Bellon JR, et al. Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343. J Clin Oncol. 2013;31:2382-2389

#Arrangoiz #BreastSurgeon #CancerSurgeon #SurgicalOncologist #CASO #CenterforAdvancedSurgicalOncology #BreastCancer

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s