Molecular Basis of HER-2-Positive Breast Cancer

– The human epidermal receptor (HER) or erbB proteins are members of the subclass I of the
receptor tyrosine kinase superfamily

– This group contains four members:

Epidermal growth factor receptor (EGFR)/erbB1/HER-1

ErbB2/HER-2/neu

ErbB3/HER-3

ErbB4/HER-4

– These proteins are made up of an extracellular ligand-binding domain, a membrane-spanning region, and a cytoplasmic domain with tyrosine kinase activity

#Arrangoiz @BreastSurgeon #CancerSurgeon #SurgicalOncologist #BreastCancer #HER2PositiveBreastCancer #CASO #CenterforAdvancedSurgicalOncology

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