PABC shares histology and some prognostic features with breast cancer occurring in other young women.
Invasive ductal carcinoma is the most common histologic subtype, followed by invasive lobular carcinoma.
The majority of tumors are grade II or III, and lymphovascular invasion is common.
However, the molecular subtypes of PABC seem to differ from those of non-PABC.
Several case-control studies have demonstrated that the hormone receptor status in PABC is more likely to be negative when compared with that in breast cancer in age-matched cohorts.
In contrast, there are conflicting reports of the HER-2 receptor status for PABC.
In a case-control study published in 1993 by Elledge and colleagues, 58% of the tumors from pregnant patients were positive for HER-2 on immunohistochemistry, whereas only 16% of age-matched non-pregnant patients had HER-2-positive tumors.
However, in a more contemporary report from the MD Anderson Cancer Center series of pregnant women by Middleton and colleagues, 28% of PABC cases had positive membrane staining for HER-2, and there was no significant difference when compared with breast carcinoma in young nonpregnant women.
My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida.
I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016.
Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida.
Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.
View all posts by Rodrigo Arrangoiz MS, MD, FACS, FSSO
Rodrigo Arrangoiz MS, MD, FACS, FSSO 