👉The Swedish Two-County Trial was the first breast screening trial to demonstrate a reduction in breast cancer mortality from screening mammography alone, showing a 30% reduction in mortality among women aged 40 to 74 years invited to screening.
👉Three decades of follow-up on this study have shown a stable effect upon mortality reduction and an increased absolute benefit in terms of lives saved.
👉Mammographic screening has been shown to be associated with a reduction in breast cancer mortality across a range of study designs, including randomized controlled trials and observational studies.
👉Although specific estimates vary, a meta-analysis of eight randomized trials demonstrated a 14% to 32% mortality reduction among women invited to screening compared with women who were not invited.
👉A recent Norwegian prospective cohort study found invitation to modern mammography screening resulted in a 28% decrease in mortality.
👉An Australian case-control study and meta-analysis of women participating in organized clinical screening programs showed a 49% mortality reduction.
👉The Swedish Organised Service Screening Evaluation Group, in an incidence-based mortality study, demonstrated a mortality reduction of 40% to 45% in women screened.
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