Accelerated Partial Breast Irradiation

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  • Accelerated partial breast irradiation includes multiple techniques such as: 
    • Interstitial brachytherapy
    • Applicator brachytherapy
    • External beam radiation therapy
  • The Groupe Européen de Curie thérapie of European Society for Radiotherapy and Oncology (GEC-ESTRO) trial:
    • Randomized 1184 patients with: 
      • Low-risk invasive carcinoma or ductal carcinoma in situ (DCIS) treated with breast-conserving surgery to either whole-breast irradiation (WBI) or APBI using multi catheter brachytherapy: 
        • The cumulative incidence of local recurrence at 5 years was: 
          • 1.44% with APBI
          • 0.92% with WBI
  • The Florence trial:
    • Randomized 520 patients to either WBI or APBI with intensity-modulated radiation therapy:
      • With a mean follow-up of 5 years: 
        • The rate of local recurrence was: 
          • 1.5% in both arms
  • The American Society of Breast Surgeons’ Mammo Site Registry found: 
    • 5-year rates of local recurrence were less than 4%
  • An older randomized trial from Hungary using interstitial APBI and electrons: 
    • 5-year local recurrence rate of 4.7%
  • It is important to recognize that these outcomes are likely due to: 
    • The highly selected, low-risk patient populations included in many of the APBI trials as evidenced by the tables / guidelines:
      • Patients tend to be: 
        • Postmenopausal
        • Tumors less than 3 cm, without DCIS
        • Node negative
        • ER-positive

#Arrangoiz #BreastSurgeon #CancerSurgeon #SurgicalOncologist #BreastCancer #CASO #CenterforAdvancedSurgicalOncology #PalmettoGeneralHospital

Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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