👉Multiple groups have attempted to define a favorable subgroup of women: – In whom the omission of adjuvant irradiation following a partial mastectomy is reasonable
👉One study (CALGB 9343): Randomized women:
– Ages 70 years and older
– Clinical stage I (T1, N0, M0) disease
– To tamoxifen for 5 years versus tamoxifen plus whole-breast irradiation
– Patients with estrogen receptor-negative tumors were excluded
– Most tumors were 2 cm or less, and surgical margins were required to be negative (defined as the absence of tumor at the inked margin)
👉Adjuvant whole-breast irradiation: – Significantly reduced the risk of local or regional failure: From 10% to 2% at 10 years
👉There were no significant differences in: – Distant disease-free survival or overall survival between the groups
👉The PRIME II trial: – Enrolled 1326 patients. – Ages 65 years and older. – With T1 to T2, node negative tumors and clear margins
👉Following breast-conserving surgery: – Patients received endocrine therapy and were randomized to adjuvant radiation therapy or no further treatmento
👉At 5 years those undergoing radiation demonstrated a reduction in local recurrence: – 4.1% vs 1.3% with no difference in survival
#Arrangoiz #CancerSurgeon #BreastSurgeon #SurgicalOncology #CASO #CenterforAdvancedSurgicalOncology #PalmettoGeneralHospital
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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO
My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida.
I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016.
Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida.
Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.
View all posts by Rodrigo Arrangoiz MS, MD, FACS, FSSO
Rodrigo Arrangoiz MS, MD, FACS, FSSO 