What is the goal of preoperative chemotherapy in inflammatory breast cancer?

  • The major determinant of overall survival:
    • In patients with inflammatory breast cancer:
      • Is the high risk of metastatic disease
  • Use of preoperative therapy in this setting:
    • Is to target any micrometastatic disease
    • To improve operability and surgical margins
    • To to evaluate response to chemotherapy
  • Neoadjuvant chemotherapy, surgery, and radiation therapy:
    • Remains the standard of care for this disease
  • A modified radical mastectomy without reconstruction:
    • Is the preferred treatment in this patient population:
      • Breast-conserving surgery:
        • Should not be offered:
          • Regardless of response to treatment
  • References:
    • Perez CA, Fields JN, Fracasso PM, et al. Management of locally advanced carcinoma of the breast. II. Inflammatory carcinoma. Cancer. 1994;74(1 Suppl):466-476.
    • Rueth NM, Lin HY, Bedrosian I, et al. Underuse of trimodality treatment affects survival for patients with inflammatory breast cancer: an analysis of treatment and survival trends from the National Cancer Database. J Clin Oncol. 2014;32(19):2018-2024.

#Arrangoiz #BreastSurgeon #CancerSurgeon #BreastCancer #Surgeon #Teacher #SurgicalOncologist

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