- A multi-institution, prospective randomized trial:
- From participating Cancer Care Ontario centers:
- Was performed from 1993 to 1996
- From participating Cancer Care Ontario centers:
- The aim of the study sought to determine:
- Whether accelerated, hypofractionation whole-breast irradiation (WBI) was as effective as the traditional 5-week schedule
- Included in the study were women:
- Who received (BCS) for invasive breast cancer with clear surgical margins and negative axillary nodes
- Participants were randomly assigned:
- To receive WBI either at the standard dose:
- Of 50.0 Gy in 25 fractions over 35 days (control group), or
- At a dose of 42.5 Gy in 16 fractions over 22 days (hypofractionated-radiation group)
- To receive WBI either at the standard dose:
- The control group included 612 patients and the hypofractionation group had 622 patients
- Results from this study:
- Indicated that the Canadian regimen:
- Was not inferior to the standard 5-week treatment regimen for women who received BCS for invasive breast cancer with clear surgical margins and negative axillary nodes
- The risk of local recurrence at 10 years was:
- 6.7% in the control group and 6.2% in the hypofractionated group
- Cosmesis at 10 years was found to be:
- Comparable between the two groups:
- With good or excellent outcomes:
- For 71.3% of women in the control group and 69.8% in the hypofractionated-radiation group
- With good or excellent outcomes:
- Comparable between the two groups:
- There was also no difference between the two groups in:
- OS and no increase in cardiac-related deaths was seen in the hypofractionated group
- Indicated that the Canadian regimen:
REFERENCES
- Whelan TJ, Pignol J-P, Levine MN, et al. Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med. 2010;362:513-520.
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