Canadian Trial

  • A multi-institution, prospective randomized trial:
    • From participating Cancer Care Ontario centers:
      • Was performed from 1993 to 1996
  • The aim of the study sought to determine:
    • Whether accelerated, hypofractionation whole-breast irradiation (WBI) was as effective as the traditional 5-week schedule
  • Included in the study were women:
    • Who received (BCS) for invasive breast cancer with clear surgical margins and negative axillary nodes
  • Participants were randomly assigned:
    • To receive WBI either at the standard dose:
      • Of 50.0 Gy in 25 fractions over 35 days (control group), or
    • At a dose of 42.5 Gy in 16 fractions over 22 days (hypofractionated-radiation group)
  • The control group included 612 patients and the hypofractionation group had 622 patients
  • Results from this study:
    • Indicated that the Canadian regimen:
      • Was not inferior to the standard 5-week treatment regimen for women who received BCS for invasive breast cancer with clear surgical margins and negative axillary nodes
    • The risk of local recurrence at 10 years was:
      • 6.7% in the control group and 6.2% in the hypofractionated group
    • Cosmesis at 10 years was found to be:
      • Comparable between the two groups:
        • With good or excellent outcomes:
          • For 71.3% of women in the control group and 69.8% in the hypofractionated-radiation group
    • There was also no difference between the two groups in:
      • OS and no increase in cardiac-related deaths was seen in the hypofractionated group

REFERENCES

  1. Whelan TJ, Pignol J-P, Levine MN, et al. Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med. 2010;362:513-520.

#Arrangoiz #BreastCancer #BreastSurgeon #CancerSurgeon #SurgicalOncologist

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