NSABP B-06

  • NSABP B-06:
    • Phase III trial of Total Mastectomy/Axillary Dissection vs Segmental Mastectomy/Axillary Dissection with or without Radiotherapy for Potentially Curable Breast Carcinoma:
      • Compared lumpectomy and ALND with or without breast radiation with MRM:
        • In patients with tumors 4 cm or less in greatest diameter
    • This trial, along with other trials, was instrumental in establishing:
      • BCS plus radiation therapy:
      • As the preferred treatment of operable breast cancer:
        • As compared to mastectomy
    • After 20 years of follow-up:
      • There are no observed differences in:
        • Overall survival
        • Distant disease-free survival:
          • Between the MRM group and the groups treated with BCS, with or without radiation
      • The hazard ratio (HR) for death with BCS alone was:
        • 1.05 (95% confidence interval [CI] 0.90–1.23; P=0.51)
      • The HR for death with BCS plus radiation was:
        • 0.97 (95% CI, 0.83–1.14; P=0.74)
          • These are comparable to MRM

#Arrangoiz #BreastSurgeon #BreastCancer #Surgeon #Teacher #CancerSurgeon #SurgicalOncologist #

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