Molecular Basis of Small Bowel Neuroendocrine Tumors

  • Carcinoid tumors arise from:
    • The enterochromaffin cells:
      • Which are neuroendocrine cells:
        • That contain serotonin
    • In the small bowel:
      • These cells reside within the epithelium
  • The pathogenesis of small bowel carcinoids is poorly understood:
    • Risk factors include:
      • Family history of cancer
      • Elevated body mass index
      • Diabetes
    • Multiple endocrine neoplasia syndromes:
      • Are associated with an elevated incidence of duodenal neuroendocrine tumors:
        • But no other known familial disorders are implicated in small bowel carcinoid tumors

#Arrangoiz #CancerSurgeon #SurgicalOncologist #Teacher #Surgeon

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