👉The NSABP B-06, Phase III Trial Total Mastectomy/Axillary Dissection vs Segmental Mastectomy/Axillary Dissection with or without Radiotherapy for Potentially Curable Breast Carcinoma.
👉Compared lumpectomy and axillary node dissection with or without breast irradiation with modified radical mastectomy (MRM) in patients with tumors 4 cm or less in greatest diameter.
👉After 20 years of follow-up, there are no observed differences in OS, or distant disease-free survival between the MRM group and the groups treated with breast-conserving surgery (BCS), with or without radiation.
👉The hazard ratio (HR) for death with BCS alone was 1.05 (95% confidence interval [CI], 0.90–1.23; P=0.51).
👉The HR for death with BCS plus radiation was 0.97 (95% CI, 0.83–1.14; P=0.74).
👉These are comparable to MRM.
👉The results of this trial demonstrating equivalent survival between the two surgical options establish BCS as a viable surgical option for most patients with invasive breast cancer.
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