Next Generation Sequencing Multigene Panel Test

👉Since the 2013 Supreme Court decision revoking patent protection for raw DNA sequences, BRCA1 and BRCA2 have been included in most multigene panel tests.

👉Next-generation sequencing tests are accurate, with analytic sensitivity and specificity measured at greater than 99.9% for detection of known pathogenic variants.

👉The 2013 Supreme Court decision also introduced competition into the genetic testing marketplace, leading to several low-cost multigene panel testing options.

👉Panel tests that include dozens of genes still identify BRCA1 and BRCA2 as the genes most frequently affected by pathologic mutation.

👉Mutations in PALB2, CHEK2, and ATM are the next most common.

👉There is a 20% to 40% chance that a multigene panel test will return a variant of uncertain clinical significance compared with about 3% for standard BRCA1 and BRCA2 tests.

#Arrangoiz #BreastSurgeon #BreastCancer #CancerSurgeon #HereditaryBreastCancer #SurgicalOncologist

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