👉Since the 2013 Supreme Court decision revoking patent protection for raw DNA sequences, BRCA1 and BRCA2 have been included in most multigene panel tests.
👉Next-generation sequencing tests are accurate, with analytic sensitivity and specificity measured at greater than 99.9% for detection of known pathogenic variants.
👉The 2013 Supreme Court decision also introduced competition into the genetic testing marketplace, leading to several low-cost multigene panel testing options.
👉Panel tests that include dozens of genes still identify BRCA1 and BRCA2 as the genes most frequently affected by pathologic mutation.
👉Mutations in PALB2, CHEK2, and ATM are the next most common.
👉There is a 20% to 40% chance that a multigene panel test will return a variant of uncertain clinical significance compared with about 3% for standard BRCA1 and BRCA2 tests.
My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida.
I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016.
Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida.
Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.
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Rodrigo Arrangoiz MS, MD, FACS, FSSO 