Multigene Panels in Breast Cancer Management

👉Next-generation sequencing technology has made it possible to test dozens of genes at one time for a fraction of the cost of classic BRCA 1 / 2 testing.

👉BRCA1 and BRCA2 are still the most common pathologic mutations identified with these tests.

👉After that, PALB2, CHEK2, and ATM are the next most common.

Distribution of Pathological Mutations Identified Using Multigene Panels.

👉Not all genes included on these multigene panels are known breast cancer predisposition genes.

👉Most of the breast cancer genes share in the task of DNA double-strand break repair.

Most of the breast cancer predisposition genes cooperate with BRCA 1 for DNA double stranded break repair.

👉There is no concern about the accuracy of these tests for detecting mutations (they are very accurate).

👉The real issue is getting the thousands of variants each test identifies classified as clinically meaningful or not.

#Arrangoiz #BreastCancer #BreastSurgeon #Arrangoiz #CancerSurgeon #SurgicalOncologist

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