Multigene Panels in Breast Cancer Management

Rodrigo Arrangoiz MS, MD, FACS, FSSO

👉Next-generation sequencing technology has made it possible to test dozens of genes at one time for a fraction of the cost of classic BRCA 1 / 2 testing.

👉BRCA1 and BRCA2 are still the most common pathologic mutations identified with these tests.

👉After that, PALB2, CHEK2, and ATM are the next most common.

Distribution of Pathological Mutations Identified Using Multigene Panels.

👉Not all genes included on these multigene panels are known breast cancer predisposition genes.

👉Most of the breast cancer genes share in the task of DNA double-strand break repair.

Most of the breast cancer predisposition genes cooperate with BRCA 1 for DNA double stranded break repair.

👉There is no concern about the accuracy of these tests for detecting mutations (they are very accurate).

👉The real issue is getting the thousands of variants each test identifies classified as clinically meaningful or not.

#Arrangoiz #BreastCancer #BreastSurgeon #Arrangoiz #CancerSurgeon #SurgicalOncologist

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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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