Nasopharyngeal Carcinoma (NPC)

• The World Health Organization (WHO) classification for NPC encompasses: 
  • Keratinizing squamous cell carcinoma (SCC):
    • Well differentiated
    • Moderately differentiated
    • Poorly differentiated
  • Nonkeratinizing carcinomas:
    • Differentiated
    • Undifferentiated  
  • Basaloid squamous cell carcinoma

• Keratinizing squamous cell carcinoma (SCC):
  • Is more common in:
    • North America
  • Is not associated with EBV
  • Comprises less than 0.3% of the NPC in southern china, 3% in Hong Kong, and 25% in North America
  • They have a conventional keratinization pattern:
    • With intercellular bridges, squamous pearls, and are graded as well differentiated, moderately differentiated, and poorly differentiated
• Non-keratinizing carcinoma undifferentiated type:
  • Is highly associated with EBV
  • Accounts for 60% of all NPCs in adults
  • Is the most frequent type in the pediatric population
• Non-keratinizing carcinoma differentiated type:
  • Accounts for 12% of NPC in Hong Kong and North America
  • Shows little to absent keratinization
  • Typically lacks a desmoplastic response
  • Has a growth pattern similar to:
    • Transitional cell carcinoma of the bladder:
      • Growth pattern may be papillary and plexiform
  • It is associated with EBV (herpes gamma virus)
  • The tumor may show prominent cystic degeneration and associated necrosis

• Rodrigo Arrangoiz MS, MD, FACS a head and neck surgeon / endocrine surgeon / surgical oncologist and is a member of Sociedad Quirúrgica S.C at the America British Cowdray Medical Center in Mexico City:

 

• Rodrigo Arrangoiz MS, MD, FACS:
  • Is a member of the American Head and Neck Society

• • He is a member of the American Thyroid Association:

Training:

• General surgery:

• Michigan State University:

• 2004 al 2010

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:

• Fox Chase Cancer Center (Filadelfia):

• 2010 al 2012

• Masters in Science (Clinical research for health professionals):

• Drexel University (Filadelfia):

• 2010 al 2012

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:

• IFHNOS / Memorial Sloan Kettering Cancer Center:

• 2014 al 2016

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