Nasopharyngeal Carcinoma (NPC)

  • The World Health Organization (WHO) classification for NPC encompasses: 
    • Keratinizing squamous cell carcinoma (SCC):
      • Well differentiated
      • Moderately differentiated
      • Poorly differentiated
    • Nonkeratinizing carcinomas:
      • Differentiated
      • Undifferentiated  
    • Basaloid squamous cell carcinoma


  • Keratinizing squamous cell carcinoma (SCC):
    • Is more common in:
      • North America
    • Is not associated with EBV
    • Comprises less than 0.3% of the NPC in southern china, 3% in Hong Kong, and 25% in North America
    • They have a conventional keratinization pattern:
      • With intercellular bridges, squamous pearls, and are graded as well differentiated, moderately differentiated, and poorly differentiated
  • Non-keratinizing carcinoma undifferentiated type:
    • Is highly associated with EBV
    • Accounts for 60% of all NPCs in adults
    • Is the most frequent type in the pediatric population
  • Non-keratinizing carcinoma differentiated type:
    • Accounts for 12% of NPC in Hong Kong and North America
    • Shows little to absent keratinization
    • Typically lacks a desmoplastic response
    • Has a growth pattern similar to:
      • Transitional cell carcinoma of the bladder:
        • Growth pattern may be papillary and plexiform
    • It is associated with EBV (herpes gamma virus)
    • The tumor may show prominent cystic degeneration and associated necrosis


  • Rodrigo Arrangoiz MS, MD, FACS a head and neck surgeon / endocrine surgeon / surgical oncologist and is a member of Sociedad Quirúrgica S.C at the America British Cowdray Medical Center in Mexico City:



  • Rodrigo Arrangoiz MS, MD, FACS:
    • Is a member of the American Head and Neck Society


    • He is a member of the American Thyroid Association:



• General surgery:

• Michigan State University:

• 2004 al 2010

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:

• Fox Chase Cancer Center (Filadelfia):

• 2010 al 2012

• Masters in Science (Clinical research for health professionals):

• Drexel University (Filadelfia):

• 2010 al 2012

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:

• IFHNOS / Memorial Sloan Kettering Cancer Center:

• 2014 al 2016
























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