Risk Factors for the Development of Breast Cancer

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  • Factors associated with the highest risk for the development of breast cancer (relative risk [RR] > 4.0) are as follows:
    • Advanced age:
      • 65 years and older
    • Atypical hyperplasia of breast:
      • Biopsy proven
    • Certain inherited genetic mutations:
      • BRCA1, BRCA2, TP53, ATM, CDH1:
        • RR between 4 and 8
    • Ductal or lobular carcinoma in situ (DCIS / LCIS):
      • RR between 8 and 10
    • Family history of early ovarian cancer:
      • Age less than 50 years
    • Multiple first-degree relatives with breast cancer
    • Ionizing radiation exposure before age 30:
      • RR between 22 and 40
    • Personal history of early breast cancer:
      • Age less than 40

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  • Factors associated with RR 2.1-4.0 for breast cancer are as follows:
    • High endogenousestrogen or testosterone level:
      • Postmenopausal
    • First full-term pregnancy:
      • After age 35 years
    • Very dense breasts:
      • Greater than 50%:
        • Compared with 11% to 25% mammographically
    • One first-degree relative with breast cancer
    • Proliferative breast diseases:
      • Atypical ductal hyperplasia
    • Certain inherited genetic mutations:
      • CHEK2
      • PTEN

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  • Factors associated with RR 1.1-2.0 for breast cancer are as follows:
    • Alcohol consumption
    • Age 30 to 35 at first full-term pregnancy
    • Diethylstilbestrol exposure in utero
    • Early menarche:
      • Age less than 12 years
    • Height:
      • Greater than 5 feet 3 inches (160 cm)
    • High socioeconomic class
    • Ashkenazi Jewish heritage
    • Personal history of breast cancer:
      • Age of onset greater than 40
    • Dense breasts:
      • 25% to 50%:
        • Compared with 11% to 25% mammographically
    • Benign breast conditions:
      • Non-atypical ductal hyperplasia
      • Fibroadenoma
      • Sclerosing adenosis
      • Microglandular adenosis
      • Papillomatosis
      • Radial scar
    • Never breastfed a child
    • Nulliparity:
      • No full-term pregnancies
    • Late menopause:
      • Age greater than 55
    • Type II diabetes mellitus
    • Obesity:
      • Post-menopausal
    • Personal history of:
      • Uterine cancer
      • Ovarian cancer
      • Colon cancer
    • Recent and long-term use of hormone replacement therapy (HRT):
      • Containing estrogen and progestin
    • Recent oral contraceptive use
    • Occupation:
      • Night shift
    • Tobacco abuse
    • Sedentary lifestyle
    • Inferior cardiovascular health
    • High bone mineral density

Schematic-diagram-of-risk-factors-and-preventions-of-breast-cancer-Age-family-history

  • Factors that reduce risk of breast cancer (RR < 1) include the following:
    • Asian, Hispanic, or Pacific islander race
    • Breastfeeding
    • Age less than 20 at first pregnancy
    • Tamoxifen use
    • Prior risk-reduction breast surgery
    • History of cervical cancer
    • History of oophorectomy
    • Exercise / active lifestyle
    • Low bone mineral density

Breast-Cancer-Risk-Factors-from-Gross-RE-2000-Breast-cancer-risk-factors

  • Rodrigo Arrangoiz MS, MD, FACS cirujano oncology y cirujano de mamá de Sociedad Quirúrgica S.C en el America British Cowdray Medical Center en la ciudad de Mexico:
    • Es experto en el manejo del cáncer de mama.

👉Es miembro de la American Society of Breast Surgeons:

Training:

• General surgery:

• Michigan State University:

• 2004 al 2010

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:

• Fox Chase Cancer Center (Filadelfia):

• 2010 al 2012

• Masters in Science (Clinical research for health professionals):

• Drexel University (Filadelfia):

• 2010 al 2012

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:

• IFHNOS / Memorial Sloan Kettering Cancer Center:

• 2014 al 2016

#Arrangoiz

#Surgeon

#Cirujano

#SurgicalOncologist

#CirujanoOncologo

#BreastSurgeon

#CirujanodeMama

#CancerSurgeon

#CirujanodeCancer

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