Thyroid Nodules Epidemiology

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  • Palpable thyroid nodules:
    • Occur in 5% of women and 1% of men in iodine-sufficient areas.
  • Thyroid nodule prevalence varies with detection mode and increases with age:
    • 2% to 6% prevalence by palpation
    • 19% to 68% prevalence by ultrasound
  • Among all thyroid nodules:
    • 7% to 15% are malignant:
      • The proportion varies with:
        • Age
        • Gender
        • Radiation exposure
        • Family history
        • Other factors
  • At least 94% of thyroid carcinomas are:
    • Differentiated thyroid cancer (DTC):
      • Primarily papillary thyroid carcinoma (PTC), and follicular thyroid carcinoma
  • The annual incidence of thyroid cancer per 100 000 person has increased from:
    • 4.6 in 1974 to 1977 to 14.4 in 2010-2013
  • In the United States in 2019:
    • 52,070 new cases of thyroid cancer are estimated to be diagnosed :
      • 14,260 in men
      • 37,810 in women
        • This figure is largely attributable to:
          • Incidentally detected subclinical disease:
    • Approximately 2,170 deaths from thyroid cancer are estimated:
      • 1,020 men
      • 1,150 women

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