Who Is at Risk for Thyroid Nodules?

Thyroid nodules can occur in anyone, but certain factors make them more likely.

👥 Common Risk Factors

Age: Nodules become more common as we get older Female sex: Women develop thyroid nodules 3–4 times more often than men Iodine imbalance: Both deficiency and excess can play a role Family history: Thyroid nodules or thyroid cancer in first-degree relatives Autoimmune thyroid disease: Hashimoto’s thyroiditis increases nodule prevalence

☢️ Higher-Risk Situations

Radiation exposure to the head and neck, especially during childhood Prior radiation therapy for acne, tonsils, or cancer (historical treatments) Certain genetic syndromes (rare, but important)

🧠 Important clarification

Having risk factors does not mean a thyroid nodule is cancer.

➡️ Even in higher-risk individuals, most nodules are benign.

🔍 What matters most?

Risk factors help guide how closely we evaluate, but ultrasound findings ultimately determine:

Cancer risk Need for biopsy Follow-up strategy

📌 Key point for patients:

A thyroid nodule should never be ignored — but it should also never cause unnecessary fear. Proper, evidence-based evaluation is the answer.

👨‍⚕️ Rodrigo Arrangoiz, MD

Surgical Oncologist – Thyroid, Head & Neck, Breast

Mount Sinai Medical Center

📚 References

Haugen BR et al. ATA Guidelines for Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid Guth S et al. Very high prevalence of thyroid nodules. Thyroid Gharib H et al. Evaluation and Management of Thyroid Nodules. Endocrine Practice

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