Breast Cancer Molecular Subtypes

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  • Breast cancer:
    • Is a heterogeneous disease:
      • Comprising multiple biological entities:
        • Each with distinct pathology, features, and clinical implications
  • Gene expression profiling in breast cancer:
    • Has identified four or five main molecular subtypes of breast cancer:
      • Recognized as distinct biological entities
  • Molecular subtypes of breast cancer:
    • Luminal A subtype:
      • Estrogen receptor (ER) positive, progesterone receptor [PR] positive and HER-2 negative with low Ki-67 [< 14%]
    • Luminal B subtype:
      • ER positive, PR positive, and HER-2 negative with high Ki-67 [> 14%]
    • Basal-like / triple-negative subtype:
      • ER negative, PR negative, and HER-2 negative
    • HER-2-amplified subtype:
      • Which can be further divided by ER status into:
        • ER negative, HER-2 positive
        • ER positive, HER-2 positive
  • Classifying breast cancer into these subtypes has led to a paradigm shift in how patients are currently stratified and treated

#Arrangoiz #CancerSurgeon #BreastSurgeon #Surgical Oncologist #MountSinaiMedicalCenter #MSMC #BreastCancer #Miami #Mexico

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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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