BRCA 1 and BRCA 2 Genes

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  •  BRCA 1 and BRCA 2 are genes:
    • That produce tumor suppressor proteins:
      • Which help repair damaged DNA
    • They are the most common gene alterations:
      • Seen in the hereditary breast cancer population
    • They are associated with an increased risk of breast cancer estimated to be:
      • 55% to 70% for BRCA 1 carriers by age 70
      • 45% to 70% in BRCA 2 carriers by age 70
    • While both BRCA 1 and BRCA 2 mutations are associated with an increased risk of breast cancer:
      • BRCA 1 breast cancers more commonly occur in:
        • Younger
        • Premenopausal women
        • Are more likely to be triple negative
        • High grade lesions
    • BRCA 1 is associated with a higher risk of ovarian cancer compared to BRCA 2:
      • With a lifetime risk of 40% to 45% in BRCA 1 carriers compared to 15% to 20% in BRCA 2 carriers
    • BRCA 2 breast cancers more closely resemble the sporadic breast cancer pattern:
      • With a predominance of hormone receptor positive cancers in women greater than 50 years
  • CHEK 2 and PALB 2 are moderate penetrance genes:
    • That are less common than BRCA mutations
    • Similar to BRCA 2 deleterious mutations:
      • CHEK 2 and PALB 2 mutations are associated with:
        • Hormone receptor positive postmenopausal breast cancer
  • References:
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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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