Breast Cancer Risk Factors

Rodrigo Arrangoiz MS, MD, FACS, FSSO
  • Atypical ductal hyperplasia (ADH):
    • Proliferative breast lesions:
      • Such as ADH confer a substantial increase in breast cancer risk of:
        • 4 to 5-fold when compared to the general population (RR 3.7-5.3)
  • In post-menopausal women a higher BMI and / or peri-menopausal weight gain:
    • Is associated with a higher risk of breast cancer
    • In the Nurses’ Health Study:
      • Women who gained 10 kg or more after menopause had a greater risk of developing breast cancer compared to those who maintained their weight (RR 1.18, 95% CI 1.03-1.35)
  • After an average of 10 years of follow-up in the Women’s Health Study:
    • Higher daily alcohol consumption was associated with an increase in invasive breast cancer risk (RR 1.43, 95% CI 1.02-2.02 for ≥ 30g alcohol (2 to 3 drinks vs. none)
  • Based on epidemiological data from 52 studies, risk ratios for breast cancer increase with the number of affected first-degree relatives:
    • 1.8 (99% CI 1.7-1.9), 2.9 (2.4-3.6), and 3.9 (2.0-7.5) respectively for one, two, and three or more affected relatives vs. none
  • There is no definitive evidence that caffeine intake is associated with breast cancer risk
  • References
    • Smart CE, Furnival CM, Lakhani SR. Chapter 17: High-Risk Lesions: ALH/LCIS/ADH. In: Kuerer HM, ed. Kuerer’s Breast Surgical Oncology. New York, NY: McGraw-Hill; 2010.
    • Eliassen AH, Colditz GA, Rosner B, Willett WC, Hankinson SE. Adult weight change and risk of postmenopausal breast cancer. JAMA. 2006;296(2):193-201.
    • Zhang SM, Lee IM, Manson JE, Cook NR, Willett WC, Buring JE. Alcohol consumption and breast cancer risk in the Women’s Health Study. Am J Epidemiol. 2007;165(6):667-676.
    • Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet. 2001;358(9291):1389-1399.
    • Ganmaa D, Willett WC, Li TY, et al. Coffee, tea, caffeine and risk of breast cancer: a 22-year follow-up. Int J Cancer. 2008;122(9):2071-2076.
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Published by Rodrigo Arrangoiz MS, MD, FACS, FSSO

My name is Rodrigo Arrangoiz I am a breast surgeon/ thyroid surgeon / parathyroid surgeon / head and neck surgeon / surgical oncologist that works at Center for Advanced Surgical Oncology in Miami, Florida. I was trained as a surgeon at Michigan State University from (2005 to 2010) where I was a chief resident in 2010. My surgical oncology and head and neck training was performed at the Fox Chase Cancer Center in Philadelphia from 2010 to 2012. At the same time I underwent a masters in science (Clinical research for health professionals) at the University of Drexel. Through the International Federation of Head and Neck Societies / Memorial Sloan Kettering Cancer Center I performed a two year head and neck surgery and oncology / endocrine fellowship that ended in 2016. Mi nombre es Rodrigo Arrangoiz, soy cirujano oncólogo / cirujano de tumores de cabeza y cuello / cirujano endocrino que trabaja Center for Advanced Surgical Oncology en Miami, Florida. Fui entrenado como cirujano en Michigan State University (2005 a 2010 ) donde fui jefe de residentes en 2010. Mi formación en oncología quirúrgica y e n tumores de cabeza y cuello se realizó en el Fox Chase Cancer Center en Filadelfia de 2010 a 2012. Al mismo tiempo, me sometí a una maestría en ciencias (investigación clínica para profesionales de la salud) en la Universidad de Drexel. A través de la Federación Internacional de Sociedades de Cabeza y Cuello / Memorial Sloan Kettering Cancer Center realicé una sub especialidad en cirugía de cabeza y cuello / cirugia endocrina de dos años que terminó en 2016.

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