What is the Optimal Operative Approach for DTC RECOMMENDATION 15 from the ATA 2025 Guidelines

  • When resection is performed for patients with thyroid cancer ≤ 2 cm without gross extra-thyroidal extension (cT1) and without metastases (cN0M0):
    • The initial surgical procedure should be a thyroid lobectomy:
      • Unless there are bilateral cancers or other indications to remove the contralateral lobe:
        • Strong recommendation, Moderate certainty evidence
  • For patients with low risk, unilateral thyroid cancer > 2 and ≤ 4 cm (cT2N0M0):
    • Thyroid lobectomy may be the preferred initial surgical treatment due to significantly lower risk and side effects:
      • However, the patient and treatment team may adopt total thyroidectomy to enable RAI administration and / or enhance follow-up based on disease features, suspicious contralateral nodularity, and / or patient preferences
    • When thyroid lobectomy is offered as initial treatment, counsel the patient about the possibility of conversion to total thyroidectomy or need for subsequent completion thyroidectomy if higher-risk factors emerge intraoperatively or postoper-
      atively:
      • Conditional recommendation, Low-moderate
        certainty evidence
  • For patients with thyroid cancer > 4 cm (cT3a), cancer of any size with gross extra-thyroidal extension (cT3b or cT4), or clinically apparent metastatic disease to lymph nodes (cN1) or distant sites (cM1):
    • The initial surgical procedure should include a total thyroidectomy with gross removal of all primary tumor and node dissection unless there are contraindications to this procedure
      • Strong recommendation, Moderate
        certainty evidence

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