- One in eight women in the United States (US):
- Will be diagnosed with breast cancer in her lifetime:
- 20% to 25% of these newly diagnosed cases;
- Will be DCIS
- 20% to 25% of these newly diagnosed cases;
- Will be diagnosed with breast cancer in her lifetime:
- In 2025:
- An estimated 59, 080 cases of DCIS:
- Will be diagnosed in US
- An estimated 59, 080 cases of DCIS:
- Widespread use of screening mammography:
- Has resulted in a 10-fold increase in the reported incidence of DCIS since the mid-1980s:
- However, since 2003:
- The incidence of DCIS has declined in women aged 50 years and older:
- Possibly due to decreased use of hormone replacement therapy
- The incidence of DCIS in women aged under 50 years:
- Continues to increase
- The incidence of DCIS has declined in women aged 50 years and older:
- However, since 2003:
- Approximately 1 in every 1,300 mammography examinations performed in US:
- Will lead to a diagnosis of DCIS:
- Representing 17% to 34% of all mammographically detected breast cancers
- Will lead to a diagnosis of DCIS:
- Before the introduction of screening mammography,:
- Most cases of DCIS were not detected:
- Until a palpable mass formed:
- But today 80% to 85% of DCIS cases are detected on screening mammography
- Until a palpable mass formed:
- Most cases of DCIS were not detected:
- Has resulted in a 10-fold increase in the reported incidence of DCIS since the mid-1980s:
- The incidence of DCIS in autopsy studies is higher than in the general population:
- Suggesting that not all DCIS lesions are clinically significant:
- Supporting concerns that most of the increase in DCIS incidence is due to the detection of nonaggressive subtypes:
- That are unlikely to progress to invasive cancer
- Supporting concerns that most of the increase in DCIS incidence is due to the detection of nonaggressive subtypes:
- Suggesting that not all DCIS lesions are clinically significant:
- The median age reported for patients with DCIS:
- Ranges from 47 to 63 years:
- Similar to that reported for patients with invasive carcinoma
- However, the age of peak incidence for DCIS:
- 96.7 per 100,000 women:
- Occurs between the ages of 65 and 69 years:
- Which is younger than for invasive breast cancer:
- For which peak incidence:
- 453.1 per 100,000 womem:
- Occurs between the ages of 75 and 79 years
- 453.1 per 100,000 womem:
- For which peak incidence:
- Which is younger than for invasive breast cancer:
- Occurs between the ages of 65 and 69 years:
- 96.7 per 100,000 women:
- Ranges from 47 to 63 years:
- The frequency of first-degree relatives having breast cancer (10% to 35%) as well as rates of deleterious mutations in the breast cancer–associated (BRCA) genes are:
- Similar for patients with DCIS as for women with invasive breast cancer
- Other risk factors for DCIS:
- Including older age, proliferative breast disease, increased breast density, nulliparity, older age at primiparity, history of breast biopsy, early menarche, late menopause, long-term use of postmenopausal hormone replacement therapy, and elevated body mass index in postmenopausal women:
- Are the same as those for invasive breast cancer
- Including older age, proliferative breast disease, increased breast density, nulliparity, older age at primiparity, history of breast biopsy, early menarche, late menopause, long-term use of postmenopausal hormone replacement therapy, and elevated body mass index in postmenopausal women:
Rodrigo Arrangoiz MS, MD, FACS, FSSO 